{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:16:50Z","timestamp":1793042210187,"version":"4.5.0"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The heteroleptic copper(II) complexes with mixed ligand systems, [Cu(\n                    <jats:bold>L<\/jats:bold>\n                    )(Bpy)](ClO\n                    <jats:sub>4<\/jats:sub>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    ;\n                    <jats:bold>1<\/jats:bold>\n                    , [Cu(\n                    <jats:bold>L<\/jats:bold>\n                    )(dmBpy)](ClO\n                    <jats:sub>4<\/jats:sub>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    ;\n                    <jats:bold>2<\/jats:bold>\n                    , [Cu(\n                    <jats:bold>L<\/jats:bold>\n                    )(Phen)](ClO\n                    <jats:sub>4<\/jats:sub>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    ;\n                    <jats:bold>3<\/jats:bold>\n                    , and [Cu(\n                    <jats:bold>L<\/jats:bold>\n                    )(dmPhen)](ClO\n                    <jats:sub>4<\/jats:sub>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    ;\n                    <jats:bold>4<\/jats:bold>\n                    (where\n                    <jats:bold>L<\/jats:bold>\n                    \u00a0=\u00a04\n                    <jats:sup>\/<\/jats:sup>\n                    \u2010(naphthalen\u20101\u2010yl)\u20102,2\n                    <jats:sup>\/<\/jats:sup>\n                    :6\n                    <jats:sup>\/<\/jats:sup>\n                    ,2\n                    <jats:sup>\/\/<\/jats:sup>\n                    \u2010terpyridine), Bpy\u00a0=\u00a02,2\n                    <jats:sup>\/<\/jats:sup>\n                    \u2010bipyridine, dmBpy\u00a0=\u00a06,6\n                    <jats:sup>\/<\/jats:sup>\n                    \u2010dimethyl\u20102,2\n                    <jats:sup>\/<\/jats:sup>\n                    \u2010bipyridine, Phen\u00a0=\u00a01,10\u2010phenanthroline and dmPhen\u00a0=\u00a02,9\u2010dimethyl\u20101,10\u2010phenanthroline) were synthesised and characterised methodically via different analytical and spectroscopic techniques. The interactions of all complexes with double\u2010stranded salmon sperm DNA (ss\u2010DNA) were monitored by UV\u2010vis spectroscopy, fluorescence spectroscopy, circular dichroism (CD) and\n                    <jats:italic>in silico<\/jats:italic>\n                    molecular docking. The binding constant (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>b<\/jats:sub>\n                    ) as well as Stern\u2010Volmer constant (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>SV<\/jats:sub>\n                    ) values of all complexes was in the order of 10\n                    <jats:sup>4<\/jats:sup>\n                    M\n                    <jats:sup>\u22121<\/jats:sup>\n                    . These studies suggested that\n                    <jats:bold>3<\/jats:bold>\n                    is showing the highest affinity towards DNA amongst the four complexes. The\n                    <jats:italic>in vitro<\/jats:italic>\n                    DNA cleavage activity was also performed using supercoiled circular (SC) plasmid DNA. Further, the cytotoxicity and evaluation of ROS generation of all complexes were analysed using MCF7 and MDA\u2010MB\u2010231 cancer cell lines. The IC\n                    <jats:sub>50<\/jats:sub>\n                    values for\n                    <jats:bold>3<\/jats:bold>\n                    against both cancer cell lines were lowest amongst the four complexes which is in accordance with the other experimental findings. The cytotoxicity experiment was also repeated with non\u2010cancer human cell line HEK293. Our study lays the foundation for the design of bio\u2010inspired mixed\u2010metal complexes, which exhibit potential for further molecular and mechanistic investigations aimed at developing cost\u2010effective, non\u2010platinum\u2010based metallodrugs.\n                  <\/jats:p>","DOI":"10.1002\/asia.202500855","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:21:32Z","timestamp":1759173692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Naphthalene Derived Terpyridine Attached Copper (II) Complexes: Effect of Planarity and Steric Hinderance on DNA Interaction"],"prefix":"10.1002","volume":"21","author":[{"given":"Shobhit","family":"Mathur","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology, Hyderabad  Kandi Sangareddy Telangana 502284 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj Kumar","family":"Kumawat","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology, Hyderabad  Kandi Sangareddy Telangana 502284 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafeesa","family":"Shahnaz","sequence":"additional","affiliation":[{"name":"DNA repair research lab Department of Biotechnology Indian Institute of Technology Hyderabad  Kandi Sangareddy Telangana 502284 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehashish","family":"Patra","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology, Hyderabad  Kandi Sangareddy Telangana 502284 India"},{"name":"DNA repair research lab Department of Biotechnology Indian Institute of Technology Hyderabad  Kandi Sangareddy Telangana 502284 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Anindya","sequence":"additional","affiliation":[{"name":"DNA repair research lab Department of Biotechnology Indian Institute of Technology Hyderabad  Kandi Sangareddy Telangana 502284 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6047-1339","authenticated-orcid":false,"given":"Somnath","family":"Maji","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology, Hyderabad  Kandi Sangareddy Telangana 502284 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"Cancer (June 2025) https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/cancer."},{"key":"e_1_2_8_2_1","volume-title":"The Cell: A Molecular Approach","author":"Cooper G. 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