{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T17:17:20Z","timestamp":1788110240504,"version":"build-2803163510"},"reference-count":73,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["CSR\u20102225 CMD\/23\u201324"],"award-info":[{"award-number":["CSR\u20102225 CMD\/23\u201324"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In this study, we report NNN pincer bis\u2010imino pyridine\u2010supported copper(II) catalysts for the sustainable, eco\u2010friendly, and practical multi\u2010component synthesis (MCS) of pyrazolines and pyrimidines driven by the acceptorless dehydrogenation of benzyl alcohols. Herein, we synthesize and characterize two well\u2010defined phosphine\u2010free NNN pincer\u2010supported copper(II) complexes,\n                    <jats:bold>C1<\/jats:bold>\n                    and\n                    <jats:bold>C2<\/jats:bold>\n                    , using IR, UV\u2013vis, HRMS, and single\u2010crystal XRD. Utilizing these complexes, we develop the first multi\u2010component synthetic route for 1,3,5\u2010trisubstituted pyrazolines (\n                    <jats:bold>TriPyz<\/jats:bold>\n                    ) from the dehydrogenative coupling of renewable benzyl alcohols and aromatic ketones with phenyl hydrazine, generating ecologically benign H\n                    <jats:sub>2<\/jats:sub>\n                    O and H\n                    <jats:sub>2<\/jats:sub>\n                    as side products. The catalytic potential of\n                    <jats:bold>C1<\/jats:bold>\n                    and\n                    <jats:bold>C2<\/jats:bold>\n                    is further extended for the MCS of 2,4,6\u2010trisubstituted pyrimidines (\n                    <jats:bold>TriPym<\/jats:bold>\n                    ) using primary alcohols, aromatic ketones, and amidine hydrochloride. Following the current methodology, we explore a broad range of\n                    <jats:bold>TriPyz<\/jats:bold>\n                    (30 examples) and\n                    <jats:bold>TriPym<\/jats:bold>\n                    (37 examples) with isolated yields of up to 94%. A series of control experiments and HRMS analysis of the catalytic cycle are carried out to reveal the possible reaction mechanism involving Cu(II)\u2010hydride as a key intermediate.\n                  <\/jats:p>","DOI":"10.1002\/asia.70278","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T15:20:57Z","timestamp":1756740057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phosphine\u2010Free NNN Pincer Supported Cu(II) Catalysts for Sustainable Multi\u2010Component Synthesis of Pyrazolines and Pyrimidines via Dehydrogenation of Renewable Primary Alcohols"],"prefix":"10.1002","volume":"20","author":[{"given":"Prashant","family":"Kukreti","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Roorkee  Roorkee Uttarakhand 247667 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parth","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Roorkee  Roorkee Uttarakhand 247667 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Roorkee  Roorkee Uttarakhand 247667 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Pattnaik","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Roorkee  Roorkee Uttarakhand 247667 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshav","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Roorkee  Roorkee Uttarakhand 247667 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaushik","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Roorkee  Roorkee Uttarakhand 247667 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1021\/cr800462w","volume":"109","author":"Candeias N. 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