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Chiral induction arises from a global\u2013local synergy: the chiral ligand's bulky side arms shape the topological portrait of the catalytic pocket, restricting substrate orientation, while local \u03c0\u2010\u03c0 interactions stabilize the transition state leading to the major product. Absence of the bulky side arms diminishes the atropo\u2010selectivity (\n                    <jats:italic>\n                      G\n                      <jats:sup>\u2021<\/jats:sup>\n                    <\/jats:italic>\n                    = 0.1 kcal\/mol), thus validating our chiral induction model. This work highlights the critical role of microenvironments within catalytic pocket in asymmetric catalysis and provides insights for designing new\u00a0catalysts.\n                  <\/jats:p>","DOI":"10.1002\/asia.70282","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:52:44Z","timestamp":1758628364000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Computational Study on a Copper\u2010Catalyzed Atroposelective Dehydro\u2010Diels\u2013Alder Reaction of Ynamide via Vinyl Cation: Mechanistic Investigations and Chiral Induction Model"],"prefix":"10.1002","volume":"20","author":[{"given":"Li\u2010Gao","family":"Liu","sequence":"first","affiliation":[{"name":"Center of Chemistry for Frontier Technologies, Department of Chemistry Zhejiang University Hangzhou Zhejiang 310027 P.R. 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