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The fluorescence titration studies revealed remarkable selectivity and reversible binding affinity of\n                    <jats:bold>TREN\u2010Nap<\/jats:bold>\n                    toward Cu(II) ions, with significant enhancement (turn\u2010on) in fluorescence emission intensity and sensitivity at the micromolar level (0.74 \u00b5M, 0.24\u00a0ppm). Notably, similar titration studies with other commonly interfering metal cations such as Zn(II), Mg(II), Cd(II), Ni(II), Co(II), Ba(II), Al(III), Pb(II), and Ca(II) caused almost negligible changes in the emission intensity, indicating their weak binding with\n                    <jats:bold>TREN\u2010Nap<\/jats:bold>\n                    . Moreover,\n                    <jats:bold>TREN\u2010Nap<\/jats:bold>\n                    displayed impressive sensing capability for Cu(II) ions even in real water samples.\n                    <jats:bold>TREN\u2010Nap<\/jats:bold>\n                    is further employed as a bioimaging agent in breast cancer (MDA\u2010MB\u2010231) and lung epithelial (L929) cells. These results affirm that\n                    <jats:bold>TREN\u2010Nap<\/jats:bold>\n                    is an excellent fluorescent \u201cturn\u2010on\u201d sensor for Cu(II) ion detection in water and biological media.\n                  <\/jats:p>","DOI":"10.1002\/asia.70309","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T11:37:47Z","timestamp":1757677067000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Simple Water\u2010Soluble TREN\u20101,8\u2010Naphthalimide Fluorescent \u201cTurn\u2010On\u201d PET Sensor for Selective and Reversible Detection of Cu(II) Ion and Application in Cellular Imaging"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2157-3081","authenticated-orcid":false,"given":"Mannanthara Kunhumon","family":"Noushija","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Palakkad  Palakkad Kerala 678623 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweata","family":"Hanson","sequence":"additional","affiliation":[{"name":"School of Biotechnology Amrita Vishwa Vidyapeetham Amritapuri Kollam Kerala 690525 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9732-2556","authenticated-orcid":false,"given":"Deivasigamani","family":"Umadevi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Palakkad  Palakkad Kerala 678623 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1502-8949","authenticated-orcid":false,"given":"Nandita","family":"Mishra","sequence":"additional","affiliation":[{"name":"School of Biotechnology Amrita Vishwa Vidyapeetham Amritapuri Kollam Kerala 690525 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3283-7847","authenticated-orcid":false,"given":"Sankarasekaran","family":"Shanmugaraju","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Palakkad  Palakkad Kerala 678623 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00240H"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1CS15245A"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2013.10.093"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2012.04.091"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr040410w"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1293-327"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2010.10.021"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/b816011m"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2022.154155"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00243J"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC00983D"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC02738K"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0DT03684F"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00491E"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6AY03006H"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563217744809"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/app10113895"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2019.06.007"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.09.010"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/chemosensors10100399"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00145"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.8b01717"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA02297F"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-009-2683-2"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar800174z"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/c39850001669"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00299"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs35467e"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10853-021-06602-w"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TC03681A"},{"key":"e_1_2_9_31_1","doi-asserted-by":"crossref","unstructured":"B.Mohan N. 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