{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:49:33Z","timestamp":1783129773734,"version":"3.54.6"},"reference-count":61,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001342","name":"Department of Science and Technology, Republic of South Africa","doi-asserted-by":"publisher","award":["IF200346"],"award-info":[{"award-number":["IF200346"]}],"id":[{"id":"10.13039\/501100001342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Structure\u2010function relationship studies are a pivotal part of the antimicrobial drug development pipeline. Compared with the extensive studies undertaken to understand structural parameters such as charge and hydrophobicity using peptides and peptidomimetics, only a few reports are available on the effect of structural constraints. In the current work, aromatic oligoamides with a flexible conformation were chosen for the antimicrobial design and structure\u2010function correlation studies. The effect of conformational rigidity on antibacterial activity was examined after side\u2010chain crosslinking. Cationic and hydrophobic groups on adjacent aromatic rings of the oligoamide sequence provided an amphiphilic topology to the molecules, and SC\u2010XRD studies confirmed the molecular design. The antimicrobial activity of the molecules against Gram\u2010negative and Gram\u2010positive bacterial strains was examined considering the effect of conformational freedom, size, charge, ratio of hydrophobic to cationic side chains, and the nature of the cationic group. Compared to the flexible analogs, the molecule with restricted bond rotations could not display higher antimicrobial activity. Our results indicate that conformational rigidity may not be a decisive factor for these aromatic oligoamides for antibacterial action when other controlling structural parameters such as charge and hydrophobicity are present.<\/jats:p>","DOI":"10.1002\/asia.70356","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T04:16:57Z","timestamp":1760588217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Examining the Role of Conformational Rigidity to Antibacterial Activity via Side\u2010Chain Crosslinking of Amphiphilic Aromatic Oligoamides"],"prefix":"10.1002","volume":"20","author":[{"given":"Payal","family":"Chauhan","sequence":"first","affiliation":[{"name":"School of Chemical Sciences Central University of Gujarat  Kundhela Gujarat 391107 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Maitra","sequence":"additional","affiliation":[{"name":"Division of Molecular Microbiology and Immunology CSIR\u2010Central Drug Research  Sector 10, Janakipuram Extension, Sitapur Road Lucknow Uttar Pradesh 226031 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5129-3355","authenticated-orcid":false,"given":"Shruti","family":"Sangwan","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Hyderabad  Prof. C. R. Rao Road Hyderabad 500046 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Kabir Hussain","family":"Shah","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences Central University of Gujarat  Kundhela Gujarat 391107 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8823-6074","authenticated-orcid":false,"given":"Sidharth","family":"Chopra","sequence":"additional","affiliation":[{"name":"Division of Molecular Microbiology and Immunology CSIR\u2010Central Drug Research  Sector 10, Janakipuram Extension, Sitapur Road Lucknow Uttar Pradesh 226031 India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad 201002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4550-2525","authenticated-orcid":false,"given":"J. Prakasha","family":"Reddy","sequence":"additional","affiliation":[{"name":"School of Applied Material Sciences Central University of Gujarat Kundhela Gujarat 391107 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2442-7255","authenticated-orcid":false,"given":"Ashwini K.","family":"Nangia","sequence":"additional","affiliation":[{"name":"School of Chemistry University of Hyderabad  Prof. C. R. Rao Road Hyderabad 500046 India"},{"name":"Department of Chemistry School of Advanced Engineering, UPES  Dehradun 248 007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7530-0663","authenticated-orcid":false,"given":"Panchami","family":"Prabhakaran","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences Central University of Gujarat  Kundhela Gujarat 391107 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00087-3"},{"key":"e_1_2_9_2_1","unstructured":"CDC Antibiotic Resistance Threats in the United States 2019 Atlanta GA: U.S. Department of Health and Human Services CDC;2019."},{"key":"e_1_2_9_3_1","unstructured":"World Health Organization Interagency Coordination Group on Antimicrobial Resistance No Time to Wait: Securing the Future from Drug\u2010 Resistant Infections Report to the Secretary General of the United Nations 2019 1\u201328."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau5480"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-015-6375-x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00194"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.55.1.2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00855"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS01026J"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00729C"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar700266f"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2019.00448"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00537"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201900204"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201410810"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2015.1076790"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00376"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SC03559C"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz352"},{"key":"e_1_2_9_20_1","first-page":"161","volume":"5","author":"Azzarito V.","year":"2013","journal-title":"Chem."},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202001716"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar900036b"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cplu.202000812"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0018-7"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0270423"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm400884w"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27051749"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811818106"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio876"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05009-11"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708254105"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201100358"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15051506"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201300077"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.6b00286"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201409964"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201409584"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202005086"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.082046199"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2006.02.007"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470559277.ch110042"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja000563a"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0222-z"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10930-018-9755-0"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.7b00114"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo050798a"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-023-03245-w"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c02481"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/c39790001180"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201300069"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8OB02535E"},{"key":"e_1_2_9_52_1","unstructured":"Deposition Numbers2411594(For11) and2411596(for12) Contain the Supplementary Crystallographic Data for This Paper. These Data Are Provided Free of Charge by the Joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe Access."},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4581"},{"key":"e_1_2_9_54_1","unstructured":"CLSI. Performance Standards for Antimicrobial Susceptibility Testing; Twenty\u2010First Informational Supplement. CLSI Document M100\u2010S21. Wayne PA: Clinical and Laboratory Standards Institute;2012."},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2019-0333"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2021.101229"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2021.04.018"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.0c01320"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806201200"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202400940"},{"key":"e_1_2_9_61_1","unstructured":"S. H.Gellman S.Hayen M. A.Schmitt F. N.Ngassa Patent No. US20040116654A1 2012."}],"container-title":["Chemistry \u2013 An Asian Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.70356","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/asia.70356","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.70356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:57:30Z","timestamp":1775807850000},"score":1,"resource":{"primary":{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/10.1002\/asia.70356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":61,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/asia.70356"],"URL":"https:\/\/doi.org\/10.1002\/asia.70356","archive":["Portico"],"relation":{},"ISSN":["1861-4728","1861-471X"],"issn-type":[{"value":"1861-4728","type":"print"},{"value":"1861-471X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,15]]},"assertion":[{"value":"2025-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70356"}}