{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T10:40:14Z","timestamp":1769424014269,"version":"3.49.0"},"reference-count":119,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To accomplish the United Nation's primary Sustainable Development Goals (SDGs), particularly SDG 3: good health and well\u2010being and SDG 9: industry, innovation, and infrastructure, it is essential to develop synthesis processes that are sustainable, cost\u2010effective, and environmentally friendly. These processes should enable the efficient and non\u2010toxic total synthesis of various drugs and natural products while minimizing impurities. This can be accomplished using inexpensive catalysts and reagents, such as zinc and its salts. This review compiles recent advancements in the field of total synthesis of bioactive natural products and active pharmaceutical molecules, encompassing the literature from the past two decades and highlighting the importance of zinc metal and its relative components in promoting a broad range of organic transformations. Like organo\u2010zinc mediated transformations, zinc\u2010mediated reductive elimination\/cleavage, zinc chloride, zinc metal, zinc triflate, zinc bromide\u2010mediated transformations, and zinc perchlorate\u2010mediated epoxide ring opening are categories in this review.<\/jats:p>","DOI":"10.1002\/asia.70380","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:22:42Z","timestamp":1760210562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Zinc Mediated Organic Transformations: Synthesis of Bioactive Natural and Medicinal Compounds"],"prefix":"10.1002","volume":"20","author":[{"given":"Nirbhay B.","family":"Hirapara","sequence":"first","affiliation":[{"name":"Inorganic Materials and Catalysis Division CSIR\u2010Central Salt &amp; Marine Chemicals Research Institute  Bhavnagar Gujarat 364002 India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad 201002 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Gayke","sequence":"additional","affiliation":[{"name":"Curia Global (former AMRI) India, Private Limited  Aurangabad Maharashtra 431136 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankush V.","family":"Biradar","sequence":"additional","affiliation":[{"name":"Inorganic Materials and Catalysis Division CSIR\u2010Central Salt &amp; Marine Chemicals Research Institute  Bhavnagar Gujarat 364002 India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad 201002 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-6941","authenticated-orcid":false,"given":"Rajesh S.","family":"Bhosale","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Ganpat University  Kherva Mehsana Gujarat 384012 India"},{"name":"Centre for Advanced Research Studies Ganpat University  Kherva Mehsana Gujarat 384012 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/ed010p223"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0160-9327(87)90282-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-0878-2_1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/om010439f"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja910083q"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201200547"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201704170"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527675944"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.01.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527618309.ch3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.3486"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c05350"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b00033"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1378376"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202303762"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo062674j"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397910903340660"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(98)00667-4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(98)00666-2"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1998-1797"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1515\/hc.2011.010"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/17415993.2022.2126319"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol300220p"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)02370-X"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397919808007034"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2011.01.101"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202100463"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1941-3801"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.5267\/j.ccl.2023.3.005"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.7b01101"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201501318"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.213926"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2019.03.041"},{"key":"e_1_2_7_34_1","volume":"17","author":"Singh B.","year":"2021","journal-title":"Spec. Issue:Single\u2010Atom Catalysts"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2023.133408"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202100735"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202300939"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b12111"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-097742-3.00213-5"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(98)00456-0"},{"key":"e_1_2_7_41_1","first-page":"1","author":"Diner C.","year":"2020","journal-title":"Org. React."},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo2020303"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.19.36"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA08163B"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01271-6"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm401958n"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0817-y"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.0c00244"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.20.247"},{"key":"e_1_2_7_50_1","first-page":"8078","volume":"22","author":"Sathish K.","year":"2024","journal-title":"Royal Society of Chemistry preprint"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b04348"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202201169"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11244-022-01602-9"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01347-3"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.1c00282"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cs15004a"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)00384-1"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200250778"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2022.2135000"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2023.133817"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(95)00396-T"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b00161"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol034894e"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol2018032"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA02011F"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/np1000895"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja2032635"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol0700862"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(92)90043-P"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c01391"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04054-14"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b03967"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo201111w"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol062748d"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja309947n"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade0032"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202406676"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0993-4"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol503625z"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.6b00163"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo050400a"},{"key":"e_1_2_7_82_1","unstructured":"X.Liangzhi H. D. H. X. D. Z. Q. Y. H. Z. L.Zhigang H.Darong D.Xiaopeng Q.Zhujin H.Yong L.Zhuangzi A Kind of Preparation Method of Butyrolactone Derivative CN 107698543 2018."},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c05378"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b01633"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr00018a006"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201914582"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol2028256"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-0966-7"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00127"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-019-0828-y"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.0c00359"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol303351y"},{"key":"e_1_2_7_93_1","first-page":"207","volume":"1","author":"Seketsu F.","year":"1995","journal-title":"Heterocycl. Commun."},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar200267a"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2014.14"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1081\/SCC-120028362"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol8001333"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)00416-7"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2004.tb00134.x"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.3c00102"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo3015209"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.49.1196"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja067870m"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.9b00326"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja030133v"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.3184\/174751913X13662146264623"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c02143"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15111392"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(97)00884-8"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol702598q"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol300200m"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja910656b"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cc11005e"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b03038"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.3390\/md10071528"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol006268c"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(02)00162-0"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja9024403"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja9804262"}],"container-title":["Chemistry \u2013 An Asian Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.70380","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T08:57:51Z","timestamp":1763456271000},"score":1,"resource":{"primary":{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/10.1002\/asia.70380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,11]]},"references-count":119,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/asia.70380"],"URL":"https:\/\/doi.org\/10.1002\/asia.70380","archive":["Portico"],"relation":{},"ISSN":["1861-4728","1861-471X"],"issn-type":[{"value":"1861-4728","type":"print"},{"value":"1861-471X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,11]]},"assertion":[{"value":"2025-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70380"}}