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Here, we report a label\u2010free, ratiometric fluorescent aptasensor for the sensitive and selective detection of QN. The sensing platform integrates a quinine\u2010specific DNA aptamer (Apt\n                    <jats:sub>QN<\/jats:sub>\n                    ) with crystal violet (CV), a triphenylmethane (TPM) dye exhibiting near\u2010infrared (NIR) emission, and fluorescein isothiocyanate (FITC) as an internal reference. Upon QN binding, CV is competitively displaced from the aptamer complex, resulting in fluorescence quenching, while FITC emission remains stable, facilitating self\u2010calibrated quantification. The aptasensor exhibits high sensitivity, rapid response within one minute and robust analytical performance in complex samples, such as lake water and soft drinks. This cost\u2010effective and efficient sensing strategy provides a reliable approach for QN monitoring in food safety and environmental applications.\n                  <\/jats:p>","DOI":"10.1002\/asia.70387","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:48:11Z","timestamp":1761018491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Sensitive and Label\u2010Free Ratiometric Fluorescent Aptasensor for Rapid Quinine Detection in Environmental and Food Samples"],"prefix":"10.1002","volume":"20","author":[{"given":"Lingli","family":"Bu","sequence":"first","affiliation":[{"name":"Linker Technology Key Laboratory College of Advanced Interdisciplinary Science and Technology Henan University of Technology  Zhengzhou 450001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhan","family":"Wei","sequence":"additional","affiliation":[{"name":"Linker Technology Key Laboratory College of Advanced Interdisciplinary Science and Technology Henan University of Technology  Zhengzhou 450001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufan","family":"Xu","sequence":"additional","affiliation":[{"name":"Linker Technology Key Laboratory College of Advanced Interdisciplinary Science and Technology Henan University of Technology  Zhengzhou 450001 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyuan","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Hainan Normal University  Haikou 571158 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhao","family":"Hu","sequence":"additional","affiliation":[{"name":"Linker Technology Key Laboratory College of Advanced Interdisciplinary Science and Technology Henan University of Technology  Zhengzhou 450001 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