{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:59:31Z","timestamp":1784336371633,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2022\/004990"],"award-info":[{"award-number":["CRG\/2022\/004990"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Nitric oxide (NO) exhibits diverse therapeutic effects in biological systems. Recently, light\u2010activated N\u2010nitrosated NO donors with fluorescence and colorimetric responses have attracted considerable attention. Anthraquinones, known for their strong colorimetric and emissive properties as well as singlet oxygen (\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) generation under light irradiation, remain largely unexplored as NO photodonors. Herein, we report the synthesis of an amphiphilic anthraquinone\u2010based NO photodonor (\n                    <jats:bold>Ant\u2010NO<\/jats:bold>\n                    ) by incorporating an N\u2010nitroso moiety. Upon light irradiation,\n                    <jats:bold>Ant\u2010NO<\/jats:bold>\n                    efficiently releases NO, accompanied by distinct fluorescence and color changes. Embedding\n                    <jats:bold>Ant\u2010NO<\/jats:bold>\n                    into the phospholipid DOPC yielded biocompatible, water\u2010dispersible liposomal nanoassemblies (\n                    <jats:bold>Ant\u2010NO.Ves<\/jats:bold>\n                    ). The NO release behavior of\n                    <jats:bold>Ant\u2010NO<\/jats:bold>\n                    and\n                    <jats:bold>Ant\u2010NO.Ves<\/jats:bold>\n                    was investigated by time\u2010dependent UV\u2013vis absorption, fluorescence spectroscopy and the Griess assay. The photoinduced NO release rate constants were 0.15445 min\n                    <jats:sup>\u22121<\/jats:sup>\n                    (\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>1\/2<\/jats:sub>\n                    \u00a0=\u00a04.5 min) in acetonitrile and 0.36187 min\n                    <jats:sup>\u22121<\/jats:sup>\n                    (\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>1\/2<\/jats:sub>\n                    \u00a0=\u00a01.9 min) for the liposomal formulation. Notably,\n                    <jats:bold>Ant\u2010NO.Ves<\/jats:bold>\n                    generated both NO and singlet oxygen upon light exposure. In vitro anticancer studies on HCT cells revealed significant light\u2010induced cytotoxicity due to the synergistic production of NO and\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    . Furthermore,\n                    <jats:bold>Ant\u2010NO.Ves<\/jats:bold>\n                    enabled real\u2010time fluorescent bioimaging in HCT cells, showing red emission during NO release and allowing visualization of intracellular NO dynamics.\n                  <\/jats:p>","DOI":"10.1002\/asia.70390","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T04:01:19Z","timestamp":1761019279000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nitric Oxide, Singlet Oxygen, and Peroxynitrite Release from Anthraquinone Photodonor Liposomes with Colorimetric and Fluorescent Readout for Anticancer Applications"],"prefix":"10.1002","volume":"20","author":[{"given":"Vinod","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Chemistry National Institute of Technology Kurukshetra  Kurukshetra Haryana 136119 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Kanika","sequence":"additional","affiliation":[{"name":"Chemical Biology Unit Institute of Nano Science and Technology (INST)  Knowledge City, Sector 81 Mohali Punjab 140306 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehan","family":"Khan","sequence":"additional","affiliation":[{"name":"Chemical Biology Unit Institute of Nano Science and Technology (INST)  Knowledge City, Sector 81 Mohali Punjab 140306 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2978-3400","authenticated-orcid":false,"given":"D. Amilan","family":"Jose","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Institute of Technology Kurukshetra  Kurukshetra Haryana 136119 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1085"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.224"},{"key":"e_1_2_9_3_1","first-page":"30","volume":"8","author":"Raij L.","year":"2006","journal-title":"J. Cell. 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