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The methodology involves a copper\u2010catalyzed intramolecular azirine ring\u2010opening followed by N\u2500N bond formation in a cascade sequence. The reaction proceeds under mild conditions without the use of hazardous reagents, offering a sustainable and practical alternative to conventional methods used for pyrazole synthesis. The protocol exhibits broad functional group tolerance, accommodating a variety of amines including aryl amines, sulfonamides, and tosylamine, affording the corresponding pyrazole derivatives in good to excellent yields. The synthetic utility of this method is further demonstrated by the rapid assembly of drug\u2010like scaffolds, including celecoxib analogs, underscoring its potential application in medicinal chemistry.\n                  <\/jats:p>","DOI":"10.1002\/asia.70407","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T04:08:10Z","timestamp":1762315690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Copper\u2010Catalyzed 2\n                    <i>H<\/i>\n                    \u2010Azirine Ring Expansion: An Efficient Route to\n                    <i>N<\/i>\n                    \u2010Substituted Pyrazoles"],"prefix":"10.1002","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4389-7820","authenticated-orcid":false,"given":"Vishal","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Chemistry Central University of Punjab  Bathinda Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2407-1328","authenticated-orcid":false,"given":"Anjali","family":"Chaturved","sequence":"additional","affiliation":[{"name":"Department of Chemistry Central University of Punjab  Bathinda Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0299-471X","authenticated-orcid":false,"given":"Bhupender","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Central University of Punjab  Bathinda Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2363-8029","authenticated-orcid":false,"given":"Muskan","family":"Bajaj","sequence":"additional","affiliation":[{"name":"Department of Chemistry Central University of Punjab  Bathinda Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0821-0101","authenticated-orcid":false,"given":"Manpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biological and Chemical Science Baba Farid College  Bathinda Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4242-5421","authenticated-orcid":false,"given":"Virender","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Central University of Punjab  Bathinda Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"141","article-title":"A Review: Biological Importance of Heterocyclic Compounds","volume":"9","author":"Mulla A. l.","year":"2017","journal-title":"Der Pharma Chemica"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA09198G"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01122"},{"key":"e_1_2_8_5_1","first-page":"209","volume-title":"Synthesis of Heterocycles in Contemporary Medicinal Chemistry","author":"Maes J Cossy B.","year":"2016"},{"key":"e_1_2_8_6_1","first-page":"216","volume-title":"Heterocyclic Chemistry in Drug Discovery","author":"Li J. 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