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In this study, we developed a series of aza\u2010IR780\u2010based heptamethine cyanine ketones that exhibit remarkable pH\u2010responsive behavior, governed by keto\u2013enol tautomerism occurring along the conjugated polyene backbone of the cyanine scaffold. Under neutral conditions, these cyanines predominantly adopt the keto form, displaying a fluorescence emission maximum at approximately 640\u00a0nm. In acidic environments, however, they shift to the enol form, resulting in a distinct fluorescence redshift to around 740\u00a0nm. This pronounced pH\u2010dependent spectral response enables real\u2010time visualization and monitoring of pH fluctuations within plant tissues. 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