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Synthesis, structural characterization, and bioactivity of heterocyclic compounds 6\u2010[2\u2010(benzyloxycarbonyl)diazen\u20101\u2010yl]\u20101\u201010\u2010phenanthroline\u20105\u2010one (BCDPO) along with 6\u2010[2\u2010(ethoxycarbonyl)diazen\u20101\u2010yl]\u20101\u201010\u2010phenanthroline\u20105\u2010one (ECDPO) and 6\u2010[2\u2010(methoxycarbonyl)diazen\u20101\u2010yl]\u20101\u201010\u2010phenanthroline\u20105\u2010one (MCDPO), which are 1,10\u2010phenanthroline\u20105,6\u2010dione (PD) derivatized with benzyl carbazate (BC), ethyl carbazate (EC), and methyl carbazate (MC), respectively, are studied. The BCDPO crystallized in triclinic system\n                    <jats:italic>P<\/jats:italic>\n                    \u20101 space group, the supramolecular BCDPO arrays stabilized involving noncovalent O\u00b7\u00b7\u00b7H and N\u00b7\u00b7\u00b7H hydrogen bond interactions as well as \u03c0\u2013\u03c0 stacking aromatic interactions. Redox properties studied through cyclic voltammetry and spectroelectrochemistry. The benzyl analog showed better anti\u2010tuberculosis (TB) activity than the methyl and ethyl analogs. The BCDPO shows good minimum inhibitory concentration (MIC) against\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (\n                    <jats:italic>Mtb<\/jats:italic>\n                    ), which is equivalent to clinically used rifampicin but better than the one of the clinically used drug candidates ethambutol. These compounds exhibit promising anticancer activity against the murine\u2010triple\u2010negative breast cancer (4T1), human breast cancer (MCF\u20107), and human prostate cancer (PC\u20103) cancer cell lines. Fluorescence confocal imaging and flow cytometry studies are performed to monitor the compound\u2010induced reactive oxygen species (ROS) generation, nuclear fragmentation, and apoptosis in cancer cell death. The carbazate functionalized phenanthroline derivatives developed are showing promising anti\u2010TB and anticancer activities.\n                  <\/jats:p>","DOI":"10.1002\/asia.70535","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T17:20:51Z","timestamp":1768411251000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis, Characterization, Crystal Structure and Anti\u2010TB and Anticancer Applications of Redox Active Phenanthroline Derivatized With Methyl\u2010, Ethyl\u2010, and Benzyl Carbazates"],"prefix":"10.1002","volume":"21","author":[{"given":"Ravallika","family":"Aluri","sequence":"first","affiliation":[{"name":"Department of Chemistry Birla Institute of Technology and Science Hyderabad Campus  Pilani Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darakhshan","family":"Begum","sequence":"additional","affiliation":[{"name":"Epigenetic Research Laboratory Department of Pharmacy Birla Institute of Technology and Science Hyderabad Campus  Pilani Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regula","family":"Sanjeev","sequence":"additional","affiliation":[{"name":"Epigenetic Research Laboratory Department of Pharmacy Birla Institute of Technology and Science Hyderabad Campus  Pilani Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ponnada","family":"Chandrasekhar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Birla Institute of Technology and Science Hyderabad Campus  Pilani Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyothi","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Birla Institute of Technology and Science Hyderabad Campus  Pilani Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmarajan","family":"Sriram","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Birla Institute of Technology and Science Hyderabad Campus  Pilani Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balaram","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Epigenetic Research Laboratory Department of Pharmacy Birla Institute of Technology and Science Hyderabad Campus  Pilani Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0518-8431","authenticated-orcid":false,"given":"Krishnan","family":"Rangan","sequence":"additional","affiliation":[{"name":"Department of Chemistry Birla Institute of Technology and Science Hyderabad Campus  Pilani Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"\u201cWorld Health Statistics Monitoring Health for the SDGs Sustainable Development Goals\u201d (2024) https:\/\/www.who.int\/publications\/i\/item\/9789240094703."},{"key":"e_1_2_10_3_1","unstructured":"\u201cWorld Health Organization. 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