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Spectroscopic analyses revealed that in the presence of the anionic liposomes (DMPG), HCQS undergoes significant microenvironmental changes, including a marginal red shift in absorption, a 17\u00a0nm blue shift in emission, and a marked reduction in fluorescence lifetime, indicating a partial localization of the drug within the liposomal hydrophobic bilayer. Steady\u2010state and time\u2010resolved anisotropy measurements revealed the restricted probe mobility in liposomal environments. However, cholesterol\u2010dependent studies indicated that increased membrane rigidity reduced the HCQS\u2010liposome association interactions. Furthermore, solubilization of the anionic liposomes by a cationic surfactant, CTAB led to the complete release of the bound HCQS, with reversibility in spectral signatures. It is suggested that due to mixed micelle formation between CTAB and the lipid molecules, the drug gets released from the liposome environment. These findings highlight the interplay of electrostatic and hydrophobic forces in governing the HCQS\u2013liposome association and provide valuable insights for rational design of liposome\u2010based drug delivery systems.<\/jats:p>","DOI":"10.1002\/asia.70589","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T21:16:14Z","timestamp":1769462174000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Interactions of Hydroxychloroquine Sulfate With DMPG Liposomes: CTAB\u2010Induced Lipid Solubilization and Subsequent Drug Release"],"prefix":"10.1002","volume":"21","author":[{"given":"Rahul","family":"Yadav","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Science Education and Research Bhopal  Bhopal Madhya Pradesh 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