{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:02:03Z","timestamp":1792447323435,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dithiocarbamates (DTCs) are privileged scaffolds in medicinal chemistry, yet inaccessible via DNA\u2010encoded libraries (DELs) due to a lack of robust on\u2010DNA synthesis. We developed a general procedure for on\u2010DNA DTC formation using a carbon disulfide (CS\n                    <jats:sub>2<\/jats:sub>\n                    ) bridging strategy. This method efficiently links diverse aliphatic secondary amines and alkyl halides under mild conditions with high conversions and excellent DNA compatibility. The utility of this method was demonstrated by constructing a prototype DEL, thereby bridging a critical gap in chemical space and facilitating the rapid discovery of DTC\u2010based therapeutics.\n                  <\/jats:p>","DOI":"10.1002\/asia.70611","type":"journal-article","created":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T06:04:36Z","timestamp":1769925876000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Bridging Strategy for On\u2010DNA Dithiocarbamate Library Synthesis"],"prefix":"10.1002","volume":"21","author":[{"given":"Yagong","family":"Wang","sequence":"first","affiliation":[{"name":"Pharmaron (Ningbo) Technology Development Co., Ltd.  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pharmaron (Ningbo) Technology Development Co., Ltd.  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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Jin","family":"Hu","sequence":"additional","affiliation":[{"name":"Pharmaron (Ningbo) Technology Development Co., Ltd.  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102092"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12030524"},{"key":"e_1_2_7_4_1","article-title":"Sodium Diethyldithiocarbamate, an AIDS Progression Inhibitor and a Copper\u2010Binding Compound, Has Proteasome\u2010Inhibitory and Apoptosis\u2010Inducing Activities in Cancer Cells","volume":"19","author":"Pang H.","year":"2007","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031317"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.2c00423"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","unstructured":"V. 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