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Bioactive glasses (BGs) that can produce hydroxyapatite (HAp) minerals through reacting with saliva provide a potential opportunity for sustainable tubular occlusion. Although effective, the promotion of BGs in DH treatment has been long suffering from their poor maneuverability in practice. Here we employ a pH neutral BGs composed of a ternary Ca\u2013P\u2013Si system, denoted as PSC, and integrate it into a polyvinyl alcohol hydrogel to construct a composite system that achieves stable tubular occlusion through induced HAp formation. The hydrogel is composed of a nanofibrous network prepared by a two\u2010step solvent exchange process, thus robustly anchoring the PSC particles to extend its intraoral retention. Its favorable aqueous permeability guarantees a free yet effective transportation of mineral precursors. In addition, the composite hydrogel preserves rapid mineralization activity, inducing HAp formation and efficiently occluding exposed tubules in vitro. These features position the composite hydrogel as a promising minimally invasive strategy for durable management of DH.<\/jats:p>","DOI":"10.1002\/asia.70672","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:17:32Z","timestamp":1773001052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioactive Glass Empowered Mineralizable Hydrogel for Effective Dentinal Tubule Occlusion"],"prefix":"10.1002","volume":"21","author":[{"given":"Yuanyuan","family":"Cui","sequence":"first","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Laboratory of Polymer Physics and Chemistry CAS Research\/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cariology and Endodontology Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cariology and Endodontology Peking University School and Hospital of Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baokui","family":"Li","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Center for Chemical Life and Health Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences Laboratory of Polymer Physics and Chemistry CAS Research\/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Interdisciplinary Research Center for Chemical Life and Health Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing 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