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However, size modulation of erythrocyte ghosts may influence their drug loading capabilities, cellular uptake, and performance as drug carriers. Herein, we have prepared micron\u2010sized\n                    <jats:bold>\n                      <jats:styled-content>N<\/jats:styled-content>\n                    <\/jats:bold>\n                    ear\n                    <jats:bold>\n                      <jats:styled-content>i<\/jats:styled-content>\n                    <\/jats:bold>\n                    nfrared\n                    <jats:bold>\n                      <jats:styled-content>E<\/jats:styled-content>\n                    <\/jats:bold>\n                    rythrocyte\n                    <jats:bold>\n                      <jats:styled-content>P<\/jats:styled-content>\n                    <\/jats:bold>\n                    articles (\u00b5NiEP) and nanosized variants (NiEP\n                    <jats:sub>400<\/jats:sub>\n                    , NiEP\n                    <jats:sub>100<\/jats:sub>\n                    ) erythrocyte\u2010derived particles using whole human blood and encapsulated with a near infrared fluorophore, indocyanine green (ICG). Size modulation of ICG\u2010loaded erythrocyte ghosts is achieved through hypotonic lysis and regulated extrusion. Physico\u2010chemical characterization confirms preservation of specific membrane proteins, including CD47, indicating immune evasion abilities across all three formulations. Size\u2010dependent cellular uptake studies in Detroit\u2010562 oropharyngeal cancer cells reveal that NiEP\n                    <jats:sub>100<\/jats:sub>\n                    demonstrates superior penetration and intracellular distribution. NIR laser\u2010mediated photothermal studies unveil NiEP\n                    <jats:sub>100<\/jats:sub>\n                    showing uptake\u2010correlated cytotoxicity enhancement (\u223c1.8\u2010fold). NiEP\n                    <jats:sub>400<\/jats:sub>\n                    shows limited therapeutic benefit (\u223c0.9\u2010fold) with moderate uptake. All displayed macrophage evasion through inherent biomimetic properties. These findings establish a vital size\u2010performance relationship for erythrocyte\u2010based particles. This study provides a foundation for developing optimized, patient\u2010tailored cancer therapeutic platforms with enhanced therapeutic indices and clinical translation potential.\n                  <\/jats:p>","DOI":"10.1002\/asia.70677","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:33:48Z","timestamp":1773002028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Engineering Size\u2010Controlled Erythrocyte\u2010Derived Particles for NIR\u2010Responsive Theranostic Applications in Oropharyngeal Carcinoma"],"prefix":"10.1002","volume":"21","author":[{"given":"Sarmistha","family":"Mazumder","sequence":"first","affiliation":[{"name":"Medical Technology Centre Indian Institute of Technology Jodhpur Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Pareek","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology All India Institute of Medical Sciences Jodhpur Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4661-066X","authenticated-orcid":false,"given":"Raviraj","family":"Vankayala","sequence":"additional","affiliation":[{"name":"Medical Technology Centre Indian Institute of Technology Jodhpur Rajasthan India"},{"name":"Department of Bioscience &amp; Bioengineering Indian Institute of Technology Jodhpur Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.905256"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.01.011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c11965"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.02.042"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7150\/ntno.77564"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.9b01139"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11110590"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201101076"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.22872"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03353743"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep02180"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano8060360"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","unstructured":"J. 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