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However, to date, no catalytic enantioselective reactions using carboxylic acid derivatives as Michael acceptors have been reported. In this study, a catalytic asymmetric hemiketalization\/oxy\u2010Michael addition cascade reaction was developed using phenyl trifluoromethyl ketone as the carbonyl reagent and chiral bifunctional thiourea catalysts. The reaction proceeded in good yields with high enantio\u2010 and diastereoselectivity. This method is applicable not only to \u03b4\u2010hydroxy\u2010\u03b1,\u03b2\u2010unsaturated ketones but also to carboxylic acid derivatives, thereby leading to synthetic flexibility based on high oxidation states.<\/jats:p>","DOI":"10.1002\/asia.70698","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:26:51Z","timestamp":1774985211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asymmetric 1,3\u2010Dioxane Synthesis by Using Bifunctional Thiourea Catalysis"],"prefix":"10.1002","volume":"21","author":[{"given":"Yusuke","family":"Ono","sequence":"first","affiliation":[{"name":"Institute For Catalysis Hokkaido University  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences Institute of Medical, Pharmaceutical, and Health Sciences Kanazawa University Kakuma\u2010machi Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Shimozawa","sequence":"additional","affiliation":[{"name":"Institute For Catalysis Hokkaido University  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Uraguchi","sequence":"additional","affiliation":[{"name":"Institute For Catalysis Hokkaido University  Sapporo Hokkaido Japan"},{"name":"List Sustainable Digital Transformation Catalyst Collaboration Research Platform Institute For Chemical Reaction Design and Discovery (ICReDD List\u2010PF) Hokkaido University  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Asano","sequence":"additional","affiliation":[{"name":"Institute For Catalysis Hokkaido University  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr00038a011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521\u20103773(20000818)39:16<2847::AID\u2010ANIE2847>3.0.CO;2\u20100"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr900019j"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0957\u20104166(00)80536\u20104"},{"key":"e_1_2_8_6_1","volume-title":"Classics in Stereoselective Synthesis","author":"Carreira E. 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