{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:07:37Z","timestamp":1783836457061,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["EMDR\/SG\/13\/2023\u20100897(IIRP\u20102023\u20100897)"],"award-info":[{"award-number":["EMDR\/SG\/13\/2023\u20100897(IIRP\u20102023\u20100897)"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Four novel mononuclear Co(II) complexes [Co(\n                    <jats:bold>L1\u2212L4<\/jats:bold>\n                    )Cl\n                    <jats:sub>2<\/jats:sub>\n                    ] (\n                    <jats:bold>1\u22124<\/jats:bold>\n                    ) have been synthesized and thoroughly characterized, where\n                    <jats:bold>L1<\/jats:bold>\n                    is N,N\u2010bis(pyridin\u20102\u2010ylmethyl)naphthalene\u20101\u2010sulfonamide,\n                    <jats:bold>L2<\/jats:bold>\n                    is N,N\u2010bis(pyridin\u20102\u2010ylmethyl)naphthalene\u20102\u2010sulfonamide,\n                    <jats:bold>L3<\/jats:bold>\n                    is 5\u2010(dimethylamino)\u2010N,N\u2010bis(pyridin\u20102\u2010ylmethyl)naphthalene\u20101\u2010sulfonamide, and\n                    <jats:bold>L4<\/jats:bold>\n                    is 4\u2010methyl\u2010N,N\u2010bis(pyridin\u20102\u2010ylmethyl)benzenesulfonamide. Comprehensive spectroscopic and analytical studies confirm that the ligands coordinate to the cobalt center in a bidentate fashion through the pyridyl nitrogen atoms, forming a rare eight\u2010membered chelate ring. Fluorescence studies revealed a ligand\u2010dependent modulation of photophysical behavior upon coordination. Complexes derived from\n                    <jats:bold>L1<\/jats:bold>\n                    and\n                    <jats:bold>L2<\/jats:bold>\n                    exhibited significant fluorescence quenching, whereas those containing\n                    <jats:bold>L3<\/jats:bold>\n                    and\n                    <jats:bold>L4<\/jats:bold>\n                    showed pronounced enhancement, indicating differing photoinduced electronic interactions between the ligands and the cobalt center. The cytotoxic potential of the complexes was further evaluated against two human breast cancer cell lines, MDA\u2010MB\u2010231 and MCF\u20107. Among the series, complex\n                    <jats:bold>2<\/jats:bold>\n                    exhibited the most pronounced cytotoxic effect, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 95.9\u00a0\u00b5M and 91.3\u00a0\u00b5M against MDA\u2010MB\u2010231 and MCF\u20107 cells, respectively. The enhanced activity of complex\n                    <jats:bold>2<\/jats:bold>\n                    is likely due to its ability to generate reactive oxygen species (ROS). These findings suggest that complex\n                    <jats:bold>2<\/jats:bold>\n                    may serve as a superior potential scaffold for the development of cobalt\u2010based cytotoxic agents with tunable electronic and photophysical properties.\n                  <\/jats:p>","DOI":"10.1002\/asia.70756","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:36:28Z","timestamp":1777574188000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sulfonamide DPA\u2010Based Mononuclear Cobalt(II) Complexes: Evaluation of ROS\u2010Driven Cytotoxicity"],"prefix":"10.1002","volume":"21","author":[{"given":"Manoj Kumar","family":"Kumawat","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Hyderabad Kandi Sangareddy Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indrajit","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Hyderabad Kandi Sangareddy Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafeesa","family":"Shahnaz","sequence":"additional","affiliation":[{"name":"DNA Repair Research Lab Department of Biotechnology Indian Institute of Technology Hyderabad Kandi Sangareddy Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharan Shanmuga Vuppaladadium","family":"Rathnam","sequence":"additional","affiliation":[{"name":"DNA Repair Research Lab Department of Biotechnology Indian Institute of Technology Hyderabad Kandi Sangareddy Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Anindya","sequence":"additional","affiliation":[{"name":"DNA Repair Research Lab Department of Biotechnology Indian Institute of Technology Hyderabad Kandi Sangareddy Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somnath","family":"Maji","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Hyderabad Kandi Sangareddy Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201010818\u20100"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5DT02281A"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201038568\u20105"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2167"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","DOI":"10.1002\/asia.202500855","article-title":"Naphthalene Derived Terpyridine Attached Copper (II) Complexes: Effect of Planarity and Steric Hinderance on DNA Interaction","volume":"21","author":"Mathur S.","year":"2025","journal-title":"Chemistry\u2014An Asian Journal"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5DT02101D"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5MD00323G"},{"key":"e_1_2_9_10_1","article-title":"Design and Synthesis of Nitrogen\u2010Rich Triazole\u2010Based Mononuclear Ru(II) Arene Complexes Toward Anticancer Activities","volume":"28","author":"Verma A.","year":"2025","journal-title":"European Journal of Inorganic Chemistry"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4DT03379E"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2018.10.006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00609F"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115816"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1DT04144D"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201039179\u20101"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.3c03696"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2012.11.019"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00209"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.9.4117\u20104128.2001"},{"key":"e_1_2_9_21_1","article-title":"Phytoagents for Cancer Management: Regulation of Nucleic Acid Oxidation, ROS, and Related Mechanisms","volume":"22","author":"Lee W. 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