{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:07:41Z","timestamp":1783836461539,"version":"3.55.0"},"reference-count":131,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The present review summarizes the developments of asymmetric organocatalytic strategies toward the construction of indole\u2010fused carbocyclic as well as heterocyclic frameworks during the time span from 2016 till date. It has been found that cycloaddition reactions of the indole derivatives with other reacting partners are prevalent in this research area which signifies that the reported strategies are based on asymmetric derivatization of the indole rings to frame\u2010fused polycycles. Due to their high abundance in naturally occurring compounds that are advantageous to biological systems, synthetic approaches toward fused polycycles with indole cores have drawn considerable focus to organic chemists. Apart from their wide distribution in several natural sources, a large numbers of marketed drugs contain indole cores as well. This article is a comprehensive documentary of the asymmetric synthesis of such polyheterocyclic through different organocatalytic processes over the past decade. Activation mode of covalent and non\u2010covalently interacting organocatalysts and their influences on asymmetric induction have been elaborated as well. The mechanistic rationale with special emphasis on stereoinduction under the catalytic activation has been explained.<\/jats:p>","DOI":"10.1002\/asia.70781","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:18:08Z","timestamp":1778645888000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Organocatalyzed Asymmetric Synthesis of Indole\u2010Fused Polycycles"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6985-1247","authenticated-orcid":false,"given":"Anup","family":"Biswas","sequence":"first","affiliation":[{"name":"Department of Chemistry Hooghly Women's College  Hooghly West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences and Humanities MCKV Institute of Engineering  Howrah West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111691"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3MD00560G"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.10.065"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3MD00677H"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medidd.2025.100208"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00549"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/b903816g"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr078412e"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07367"},{"key":"e_1_2_10_11_1","unstructured":"Nobel Prize in Chemistry(2021) https:\/\/www.nobelprize.org\/prizes\/chemistry\/2021\/summary\/."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200601872"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.539"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar200338s"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202203368"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr068388p"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr0684016"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201509693"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201600465"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201501619"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201602793"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2016.08.077"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA19916J"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8QO01042K"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b03251"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201800034"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8QO01406J"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127063"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c02309"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.202400061"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202404935"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202004553"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202100250"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c01182"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202401431"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00060"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b01411"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b03277"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b02820"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201810879"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b01624"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC01444F"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcat.2021.111647"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-019-0188-2"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.9b03163"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b08510"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c01447"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c00418"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c01221"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.2c00952"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3QO00377A"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.3c01194"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.4c02434"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52823-3"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202316739"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202500016"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3OB00212H"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201501175"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201600931"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201601020"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b02898"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.7b01731"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201603049"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201700203"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7OB01059A"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b02718"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.3079"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6QO00446F"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201701521"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8QO00014J"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8OB01427B"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201807069"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201901955"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.0c01123"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c01812"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c00748"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.2c02303"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2019.09.008"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202017268"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1522-9361"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202011267"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202400533"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4OB01365D"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28211-0"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202305450"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3QO01563G"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.3c02476"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3QO01558K"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202401160"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.4c02084"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fmre.2022.01.002"},{"key":"e_1_2_10_92_1","first-page":"30","article-title":"Asymmetric Organocatalytic (3 + 2) Annulation of Propargylic Alcohols with Indolylnaphthalenols: Synergistic Construction of Axial and Central Chirality","volume":"10","author":"Jia Y.","year":"2023","journal-title":"Journal of Organic Chemistry"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202410581"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.4c01772"},{"key":"e_1_2_10_95_1","first-page":"1629","article-title":"Catalytic Asymmetric (3 + 3) Cycloaddition between Different 2\u2010Indolylmethanols","volume":"67","author":"Li T.","year":"2024","journal-title":"Science China Chemistry"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CC03230F"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC05174A"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4QO01047G"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202316454"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.202400900"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gresc.2024.01.002"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202422951"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.6023\/cjoc202500004"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c14276"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c02145"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.70263"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c12042"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c01600"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c02216"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c01253"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b00012"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.9b01234"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202106514"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c00489"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c00188"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA24288F"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.0c00957"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201511231"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201707183"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.100840"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.7b00733"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.9b00430"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c01406"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b01945"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b02361"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.201800368"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b04615"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC06357J"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4QO01557F"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202206501"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1QO01785C"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202507804"}],"container-title":["Chemistry \u2013 An Asian Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.70781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/asia.70781","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.70781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:27:19Z","timestamp":1783834039000},"score":1,"resource":{"primary":{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/10.1002\/asia.70781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":131,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/asia.70781"],"URL":"https:\/\/doi.org\/10.1002\/asia.70781","archive":["Portico"],"relation":{},"ISSN":["1861-4728","1861-471X"],"issn-type":[{"value":"1861-4728","type":"print"},{"value":"1861-471X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70781"}}