{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:31:00Z","timestamp":1790803860534,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001332","name":"Council for Scientific and Industrial Research, South Africa","doi-asserted-by":"publisher","award":["31\/0028(23891)\/2025\u2010EMR\u2010I"],"award-info":[{"award-number":["31\/0028(23891)\/2025\u2010EMR\u2010I"]}],"id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The rational integration of antagonistic catalytic sites within robust porous architectures remains a critical challenge for sustainable multicomponent reactions to synthesize pharmacologically active molecules. Herein, we report a thermo\u2010chemically stable, mixed\u2010ligand Ni(II)\u2010based pillar\u2010layered metal\u2010organic framework (MOF), featuring activation\u2010induced open metal sites and pore\u2010confined Lewis basic centres. This bifunctional framework acts as an efficient heterogeneous catalyst for one\u2010pot Knoevenagel\u2013Michael multicomponent reactions, enabling the rapid synthesis of structurally diverse 2\u2010amino\u20103\u2010cyano\u20104H\u2010pyrans under mild conditions with low catalyst loading. The synthesis of 4H\u2010pyrans is promoted by the synergistic interplay between Lewis acidic metal centres and framework\u2010integrated basic sites, as corroborated by control experiments and analyte\u2010responsive emission modulation. The protocol accommodates twenty\u2010six electronically diverse substrates and affords bioactive pyran derivatives in excellent yields. Notably, the confined pore environment imparts distinct size\u2010selectivity, restricting bulky substrates and demonstrates molecular\u2010dimension\u2010controlled catalysis. The framework exhibits remarkable recyclability, structural robustness, and negligible metal leaching, outperforming many reported catalytic systems. Importantly, eight 4H\u2010pyrans were structurally confirmed in their purest form by single\u2010crystal X\u2010ray diffraction, alongside other spectroscopic characterizations. This work highlights a rational platform for designing bifunctional MOF catalysts to promote green organic synthesis through the synergistic cooperation of antagonistic functionalities confined within porous architectures.<\/jats:p>","DOI":"10.1002\/asia.70882","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:21:03Z","timestamp":1783930863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Robust Mixed\u2010Ligand Ni(II)\u2010framework With Pore\u2010Engineered Lewis Acid\u2013Base Sites for Size\u2010selective and One\u2010Pot Mild Synthesis of Bioactive 4H\u2010Pyrans"],"prefix":"10.1002","volume":"21","author":[{"given":"Rudra","family":"Chand","sequence":"first","affiliation":[{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"},{"name":"Inorganic Materials &amp; Catalysis Division CSIR\u2010Central Salt &amp; Marine Chemicals Research Institute  Bhavnagar Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bapan","family":"Maji","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"},{"name":"Inorganic Materials &amp; Catalysis Division CSIR\u2010Central Salt &amp; Marine Chemicals Research Institute  Bhavnagar Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha Pratim","family":"Mondal","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"},{"name":"Inorganic Materials &amp; Catalysis Division CSIR\u2010Central Salt &amp; Marine Chemicals Research Institute  Bhavnagar Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3838-4180","authenticated-orcid":false,"given":"Subhadip","family":"Neogi","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research (AcSIR)  Ghaziabad India"},{"name":"Inorganic Materials &amp; Catalysis Division CSIR\u2010Central Salt &amp; Marine Chemicals Research Institute  Bhavnagar Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400615v"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c11071"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201006515"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44160\u2010022\u201000085\u20106"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00128G"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c02551"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.2c01030"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC00522H"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5TA07734F"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202401248"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201900558"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/sc400312n"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.06.056"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2003.12.069"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2011.05.052"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.133870"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.4c01029"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.6915"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.4577"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202501767"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040\u20104020(01)87029\u20100"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202411300"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3RA43514H"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/17518253.2012.691183"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.04.017"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.30492\/ijcce.2020.32997"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtusci.2014.09.008"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929\u2010018\u20100069\u20106"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202315075"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202414271"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00905"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00510"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202404085"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202508504"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202500324"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.5c03841"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c23129"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c07205"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.energyfuels.5c06120"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4GC05154H"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2025.217114"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00757"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00250A"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201605446"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c01459"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202211523"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889802022112"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/cg500498k"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.2c05673"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.01.053"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.132301"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1QI00345C"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules31010113"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41560\u2010017\u20100078\u20108"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.6c00060"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.08.026"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3RA46598E"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201010774\u2010z"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.3557"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202502681"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b04887"}],"container-title":["Chemistry \u2013 An Asian Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.70882","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/asia.70882","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/asia.70882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T17:03:02Z","timestamp":1784048582000},"score":1,"resource":{"primary":{"URL":"https:\/\/aces.onlinelibrary.wiley.com\/doi\/10.1002\/asia.70882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":61,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/asia.70882"],"URL":"https:\/\/doi.org\/10.1002\/asia.70882","archive":["Portico"],"relation":{},"ISSN":["1861-4728","1861-471X"],"issn-type":[{"value":"1861-4728","type":"print"},{"value":"1861-471X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70882"}}