{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:16:44Z","timestamp":1787620604650,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Polypeptides are emerging as an integral part of biomaterial research because of their unique ability to mimic natural protein\u2010like secondary structures in water; however, they require a multistep self\u2010assembly process to yield desired nano\u2010sized objects for intended biomedical applications. In this study, we report a one\u2010pot photo\u2010crosslink strategy for stable polypeptide nanoparticle self\u2010assembly by ring\u2010opening polymerization\u2010induced self\u2010assembly (ROPISA) route. For this purpose, a cinnamoyl functionalized\n                    <jats:sc>l<\/jats:sc>\n                    \u2010serine based N\u2010carboxyanhydride (NCA) monomer is designed and subjected to ROPISA using PEG\u2010amine as a hydrophilic macroinitiator in water which produced stable opalescent dispersions of amphiphilic PEG\u2010polypeptide di\u2010block copolymers having narrow molecular weights. Dynamic light scattering and HR\u2010TEM analysis revealed the formation of spherical nanoparticles of 25\u201330\u00a0nm in size. The cinnamoyl anchored polypeptides underwent [2+2] cycloaddition under UV irradiation (265\u00a0nm) and the occurrence of the photo\u2010crosslinking and its kinetics is studied by UV\u2013visible spectroscopy. Notably, the nanoparticle size and structural integrity is remained unchanged and the particle morphology is found to be very stable. The core\u2010cross\u2010linked nanoparticles is found to be stable and behave as efficient scaffold for loading both water soluble and insoluble cargoes. This report opens an avenue to access photo\u2010crosslinkable polypeptide nano\u2010assemblies in the literature.\n                  <\/jats:p>","DOI":"10.1002\/asia.70912","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:33:27Z","timestamp":1785933207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ROPISA Synthetic Strategy for Photo\u2010Crosslinked Aqueous Polypeptide Nano\u2010Assemblies"],"prefix":"10.1002","volume":"21","author":[{"given":"Akshaya Maria","family":"Prasad","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Science Education and Research, Pune (IISER Pune)  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parshuram","family":"Kambale","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Science Education and Research, Pune (IISER Pune)  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