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In this regard, antibacterial photodynamic therapy (aPDT) has gained increasing attention as a non\u2010invasive approach that utilizes light\u2010activated photosensitizers to generate targeted reactive oxygen species (ROS), leading to rapid bacterial inactivation with minimal resistance development. Among various photosensitizers, Zn(II) complexes have shown promising potential due to their favorable biocompatibility, photophysical properties, and tunable coordination chemistry. Unlike heavy\u2010metal photosensitizers, Zn(II) complexes owe their photophysical performance to extended macrocyclic \u03c0\u2010systems rather than metal spin\u2010orbit coupling, making them uniquely suited for biocompatible aPDT. This review critically examines recent advances in Zn(II)\u2010based complexes as photosensitizers, including phthalocyanines, porphyrins, chlorins, and curcumin systems, highlighting structure\u2013activity relationships (SARs), ROS generation mechanisms, and antibacterial efficacy against both Gram\u2010positive and Gram\u2010negative pathogens, including multidrug\u2010resistant strains. Key design strategies such as cationic functionalization, polymer conjugation, and hybridization with antimicrobial peptides are discussed. Additionally, current limitations, including aggregation, limited penetration, translational challenges, and future perspectives for clinical translation are also outlined. This review aims to provide a comprehensive framework for the rational design of next\u2010generation Zn(II)\u2010photosensitizers for effective aPDT.<\/jats:p>","DOI":"10.1002\/asia.70977","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T01:54:26Z","timestamp":1788746066000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recent Advances in Zinc(II)\u2010Complexes for Antibacterial Photodynamic Therapy"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5724-3623","authenticated-orcid":false,"given":"Rajesh","family":"Kushwaha","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology (BHU)  Varanasi Uttar Pradesh 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