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In this study, oxidized alginate (Alg\u2010O) was covalently crosslinked with guanidine hydrazide (GH) through acid\u2010catalysed hydrazone linkages to yield stable Alg\u2010Gl hydrogels at ambient conditions. Systematic evaluation of gelation parameters demonstrated that both pH and organocatalyst selection modulate gelation kinetics and minimum gelation concentration, with mildly acidic environments and anthranilic acid catalysis accelerating crosslinking and generating denser network structures. Anthranilic acid catalysis further enabled efficient Alg\u2010Gl hydrogelation at neutral pH, addressing common limitations of hydrazone chemistry under physiological conditions. The dynamic covalent network permitted encapsulation of sensitive therapeutic payloads such as Vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    without compromising cargo integrity or bioactivity. Alg\u2010Gl hydrogels exhibited sustained, biphasic VB\n                    <jats:sub>12<\/jats:sub>\n                    release with reduced initial burst and prolonged release compared to conventional alginate matrices. These findings highlight the potential of organocatalytically modulated Alg\u2010Gl hydrogels as a platform for controlled drug delivery and broader biomedical applications, including responsive therapeutics and tissue engineering scaffolds.\n                  <\/jats:p>","DOI":"10.1002\/asia.70980","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T01:50:55Z","timestamp":1788745855000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Organocatalytically\u2010Tuned In Situ Formed Alginate Hydrogel Enables Sustained Therapeutic Release"],"prefix":"10.1002","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2200-9666","authenticated-orcid":false,"given":"Nikita","family":"Das","sequence":"first","affiliation":[{"name":"(Organic)Material Science &amp; Engineering Lab Vellore Institute of Technology  Vellore Tamil Nadu 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