{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:58:17Z","timestamp":1790686697177,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aces.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry \u0097 An Asian Journal"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The Sonogashira coupling reaction holds an irreplaceable position in fields such as drug synthesis, natural product preparation, and functional material development. Through the integration of technical means such as mechanochemistry and microwave irradiation with efficient catalytic systems, the greening and high efficiency of the Sonogashira reaction process are achieved. This paper systematically reviews the research progress of solvent\u2010free Sonogashira coupling reactions, focusing on classifying and elaborating on the design principles, catalytic performance, and reaction mechanisms of palladium\u2010catalyzed, copper\u2010catalyzed, palladium\u2010copper co\u2010catalyzed, and other novel catalytic systems. Both standard Sonogashira (Ar\u2010X) and acyl\u2010Sonogashira (Ar\u2010COCl coupling) reactions are involved. It also analyzes the advantages and limitations of each system in terms of substrate compatibility, catalytic activity, and cyclic stability, providing a reference for the theoretical research and practical application of solvent\u2010free Sonogashira coupling reactions.<\/jats:p>","DOI":"10.1002\/asia.70993","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:31:17Z","timestamp":1789965077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recent Advances in Solvent\u2010Free Sonogashira Coupling"],"prefix":"10.1002","volume":"21","author":[{"given":"Baolei","family":"Huang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shandong University of Technology  Zibo People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shandong University of Technology  Zibo People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shandong University of Technology  Zibo People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shandong University of Technology  Zibo People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3963-7346","authenticated-orcid":false,"given":"Caixia","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shandong University of Technology  Zibo People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Shandong University of Technology  Zibo People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"205","article-title":"Palladium\u2010Catalyzed Cross\u2010Coupling Reactions in the Synthesis of Pharmaceuticals, Organometallics in Process Chemistry","volume":"6","author":"King A. 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