{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:22:05Z","timestamp":1790238125129,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T00:00:00Z","timestamp":1261008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>: To determine the effect of serotonin transporter polymorphism promoter region (5\u2010HTTPLR) genotypic variation (low, intermediate, and high expression groups) on response to escitalopram treatment of children and adolescents with autism spectrum disorders (ASDs). <jats:italic>Method<\/jats:italic>: The study used a forced titration, open label design, with genotype blind until study completion. Participants were children and adolescents aged 4\u201317 years of age with a confirmed ASD (autistic disorder, Asperger's disorder, or pervasive developmental disorder, not otherwise specified). <jats:italic>Results<\/jats:italic>: There was an interaction between genotype group and time on the Aberrant Behavior Checklist (ABC) Irritability Subscale (primary outcome variable) (linear maximum marginal likelihood estimation=\u22124.84, <jats:italic>Z<\/jats:italic>=\u22122.89, SE=1.67, <jats:italic>P<\/jats:italic>=0.004). Examination of baseline to last visit revealed that a genotype grouping based on a previous study of platelet 5\u2010HT uptake revealed less response in the genotype group that had S\/S genotype for 5\u2010HTTLPR and did not have a diplotype in intron 1 previously shown to be associated with increased platelet 5\u2010HT uptake. <jats:italic>Conclusion<\/jats:italic>: This genotype\u2010blind, prospective pharmacogenetic study found the group of subjects with associated with the lowest platelet 5\u2010HT uptake from previous study had the smallest reduction in ABC\u2010Irritability scores after open label treatment with escitalopram. Replication is necessary to confirm these findings.<\/jats:p>","DOI":"10.1002\/aur.109","type":"journal-article","created":{"date-parts":[[2009,12,18]],"date-time":"2009-12-18T00:01:25Z","timestamp":1261094485000},"page":"1-7","source":"Crossref","is-referenced-by-count":47,"title":["A pharmacogenetic study of escitalopram in autism spectrum disorders"],"prefix":"10.1002","volume":"3","author":[{"given":"Thomas","family":"Owley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille 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