{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T04:34:44Z","timestamp":1782016484685,"version":"3.54.5"},"reference-count":73,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,8,4]],"date-time":"2012-08-04T00:00:00Z","timestamp":1344038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>Atypical visuospatial processing is commonly described in autism spectrum disorders (<jats:styled-content style=\"fixed-case\">ASDs<\/jats:styled-content>); however the specific neurobiological underpinnings of this phenomenon are poorly understood. Given the extensive evidence suggesting <jats:styled-content style=\"fixed-case\">ASDs<\/jats:styled-content> are characterized by abnormal neural connectivity, this study aimed to investigate network connectivity during visuospatial processing in <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>. Twenty\u2010two males with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> without intellectual disability and 22 individually matched controls performed a mental rotation task during functional magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) in which two rotated stimuli were judged to be same (\u201c<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ame <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>rials\u201d) or mirror\u2010imaged (\u201c<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>irror <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>rials\u201d). Behavioral results revealed a relative advantage of mental rotation in the <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> group\u2014controls were slower responding to the more difficult <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>irror <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>rials than <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ame <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>rials whereas the <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> group completed <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>irror <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>rials and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ame\u2010trials at similar speeds. In the <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> group, brain activity was reduced in frontal, temporal, occipital, striatal, and cerebellar regions and, consistent with previous literature, functional connectivity between a number of brain regions was reduced. However, some connections appeared to be conserved and were recruited in a qualitatively different way by the two groups. As task difficulty increased (on <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>irror <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>rials), controls tended to increase connections between certain brain regions, whereas the <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> group appeared to suppress connections between these regions. There was an interesting exception to this pattern in the visual cortex, a finding that may suggest an advantage in early visual perceptual processing in <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>. Overall, this study has identified a relative advantage in mental rotation in <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> that is associated with aberrant neural connectivity and that may stem from enhanced visual perceptual processing. <jats:italic><jats:bold>Autism Res<\/jats:bold> 2012, 5: 314\u2013330.<\/jats:italic> \u00a9 2012 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/aur.1245","type":"journal-article","created":{"date-parts":[[2012,8,4]],"date-time":"2012-08-04T18:51:12Z","timestamp":1344106272000},"page":"314-330","source":"Crossref","is-referenced-by-count":34,"title":["Atypical Visuospatial Processing in Autism: Insights from Functional Connectivity Analysis"],"prefix":"10.1002","volume":"5","author":[{"given":"Jane","family":"McGrath","sequence":"first","affiliation":[{"name":"Department of Psychiatry Trinity Centre for Health Sciences St. James's Hospital  Dublin 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