{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T07:26:42Z","timestamp":1789370802324,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T00:00:00Z","timestamp":1346976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2012,12]]},"abstract":"Velo\u2010cardio\u2010facial syndrome (VCFS<\/jats:styled-content>; 22q11.2 deletion syndrome) results from a genetic mutation that increases risk for A<\/jats:styled-content>utism S<\/jats:styled-content>pectrum D<\/jats:styled-content>isorder (ASD<\/jats:styled-content>). We compared T<\/jats:styled-content>heory of M<\/jats:styled-content>ind (ToM<\/jats:styled-content>) skills in 63 individuals with VCFS<\/jats:styled-content> (25% with an ASD<\/jats:styled-content> diagnosis) and 43 typically developing controls, and investigated the relationship of ToM<\/jats:styled-content> to reciprocal social behavior. We administered a video\u2010based task to assess mentalizing at two sites U<\/jats:styled-content>niversity of C<\/jats:styled-content>alifornia, L<\/jats:styled-content>os A<\/jats:styled-content>ngeles (UCLA<\/jats:styled-content>) and S<\/jats:styled-content>tate U<\/jats:styled-content>niversity of N<\/jats:styled-content>ew Y<\/jats:styled-content>ork (SUNY<\/jats:styled-content>) U<\/jats:styled-content>pstate M<\/jats:styled-content>edical U<\/jats:styled-content>niversity. The videos depicted interactions representing complex mental states (ToM<\/jats:styled-content> condition), or simple movements (R<\/jats:styled-content>andom condition). Verbal descriptions of the videos were rated for I<\/jats:styled-content>ntentionality (i.e. mentalizing) and A<\/jats:styled-content>ppropriateness. Using R<\/jats:styled-content>epeated M<\/jats:styled-content>easures analysis of variance (ANOVA<\/jats:styled-content>), we assessed the effects of VCFS<\/jats:styled-content> and ASD<\/jats:styled-content> on I<\/jats:styled-content>ntentionality and A<\/jats:styled-content>ppropriateness, and the relationship of mentalizing to S<\/jats:styled-content>ocial R<\/jats:styled-content>esponsiveness S<\/jats:styled-content>cale (SRS<\/jats:styled-content>) scores. Results indicated that individuals with VCFS<\/jats:styled-content> overall had lower I<\/jats:styled-content>ntentionality and A<\/jats:styled-content>ppropriateness scores than controls for ToM<\/jats:styled-content> but not for R<\/jats:styled-content>andom scenes. In the SUNY<\/jats:styled-content> sample, individuals with VCFS<\/jats:styled-content>, both with and without ASD<\/jats:styled-content>, performed more poorly than controls on the ToM<\/jats:styled-content> condition; however, in the UCLA<\/jats:styled-content> sample, only individuals with VCFS<\/jats:styled-content> without ASD<\/jats:styled-content> performed significantly worse than controls on the ToM<\/jats:styled-content> condition. Controlling for site and age, performance on the ToM<\/jats:styled-content> condition was significantly correlated with SRS<\/jats:styled-content> scores. Individuals with VCFS<\/jats:styled-content>, regardless of an ASD<\/jats:styled-content> diagnosis, showed impairments in the spontaneous attribution of mental states to abstract visual stimuli, which may underlie real\u2010life problems with social interactions. A better understanding of the social deficits in VCFS<\/jats:styled-content> is essential for the development of targeted behavioral interventions. Autism Res<\/jats:bold> 2012, 5: 407\u2013418<\/jats:italic>. \u00a9 2012 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/aur.1252","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T12:41:53Z","timestamp":1347021713000},"page":"407-418","source":"Crossref","is-referenced-by-count":33,"title":["Deficits in Mental State Attributions in Individuals with 22q11.2 Deletion Syndrome (V<\/scp>elo\u2010Cardio\u2010Facial Syndrome)"],"prefix":"10.1002","volume":"5","author":[{"given":"Jennifer S.","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petya D.","family":"Radoeva","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Physiology State University of New York Upstate 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