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Therefore, we designed this study to identify differences (and\/or similarities) in the microbiota of children with autism (without gastrointestinal dysfunction: <jats:italic><jats:styled-content style=\"fixed-case\">n<\/jats:styled-content><\/jats:italic>\u2009=\u200923; with gastrointestinal dysfunction: <jats:italic><jats:styled-content style=\"fixed-case\">n<\/jats:styled-content><\/jats:italic>\u2009=\u200928) and their neurotypical siblings (<jats:italic><jats:styled-content style=\"fixed-case\">n<\/jats:styled-content><\/jats:italic>\u2009=\u200953) who share a similar environment using bacterial tag\u2010encoded <jats:styled-content style=\"fixed-case\">FLX<\/jats:styled-content> amplicon pyrosequencing. Regardless of the diagnosis and sociodemographic characteristics, overall, <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>irmicutes (70%), <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>acteroidetes (20%) and <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>roteobacteria (4%) were the most dominant phyla in samples. Results did not indicate clinically meaningful differences between groups. The data do not support the hypothesis that the gastrointestinal microbiota of children with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> plays a role in the symptomatology of <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>. Other explanations for the gastrointestinal dysfunction in this population should be considered including elevated anxiety and self\u2010restricted diets. <jats:italic><jats:bold>Autism Res<\/jats:bold> 2012, 5: 419\u2013427.<\/jats:italic> \u00a9 2012 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/aur.1253","type":"journal-article","created":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T17:24:13Z","timestamp":1348161853000},"page":"419-427","source":"Crossref","is-referenced-by-count":189,"title":["Molecular Characterisation of Gastrointestinal Microbiota of Children With Autism (With and Without Gastrointestinal Dysfunction) and Their Neurotypical Siblings"],"prefix":"10.1002","volume":"5","author":[{"given":"Shakuntla V.","family":"Gondalia","sequence":"first","affiliation":[{"name":"Swinburne Autism Bio\u2010Research Initiative (SABRI) Faculty of Life and Social Sciences Swinburne University of Technology  Hawthorn Victoria 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