{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:11:29Z","timestamp":1761059489549},"reference-count":78,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T00:00:00Z","timestamp":1363219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>It has been suggested that atypical amygdala function contributes to the social impairments characteristic of autism spectrum disorders (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>s). Previous research has demonstrated that adolescents and adults with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> generate normal response during a fear\u2010potentiated startle paradigm, suggesting this aspect of amygdala function is intact and may not account for the social dysfunction associated with the condition. The amygdala also plays a crucial role in the expression of anxiety and may contribute to high rates of reported anxiety in individuals with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>. The present study partially replicates prior work by examining the fear\u2010potentiated startle response in adolescents with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>, and extends this to investigate the relationship between startle response and anxiety. Eyeblink magnitude and latency (electromyographic activity; <jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content>) were collected from 20 adolescents with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> and 19 typically developing (<jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content>) age\u2010matched adolescents during a fear\u2010potentiated startle paradigm. Parent\u2010report and self\u2010report of anxiety and additional psychiatric symptoms were collected. Parental reports indicated higher rates of associated psychopathology in adolescents with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> compared with <jats:styled-content style=\"fixed-case\">TD<\/jats:styled-content> adolescents. Consistent with previous results, both groups showed normal potentiated startle response, and no group differences in <jats:styled-content style=\"fixed-case\">EMG<\/jats:styled-content> were found. Symptoms of anxiety and level of social impairment were unrelated to startle response. These findings held for all levels of anxiety, suggesting that within the context of the fear\u2010potentiated startle paradigm, amygdala response is not associated with degree of atypical social or emotional functioning in <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>. <jats:italic><jats:bold>Autism Res<\/jats:bold> 2013, \u25cf\u25cf: \u25cf\u25cf\u2013\u25cf\u25cf.<\/jats:italic> \u00a9 2013 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/aur.1289","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T06:39:28Z","timestamp":1363329568000},"page":"320-331","source":"Crossref","is-referenced-by-count":17,"title":["Fear\u2010Potentiated Startle Response Is Unrelated to Social or Emotional Functioning in Adolescents With Autism Spectrum Disorders"],"prefix":"10.1002","volume":"6","author":[{"given":"Lindsey","family":"Sterling","sequence":"first","affiliation":[{"name":"Department of 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