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We focused on individuals with high\u2010functioning autism spectrum disorder (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>, to decrease heterogeneity caused by large variation in the cognitive profile. Previous <jats:styled-content style=\"fixed-case\">DTI<\/jats:styled-content> studies of <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> have mainly focused on finding local changes in fractional anisotropy (<jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>) and mean diffusivity (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>), two indexes used to characterize microstructural properties of <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>. Although the local or voxel\u2010based approaches may be able to provide detailed information in terms of location of the observed differences, such results are known to be highly sensitive to partial volume effects, registration errors, or placement of the regions of interest. Therefore, we performed global histogram analyses of (a) whole\u2010brain tractography results and (b) skeletonized <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> masks. In addition to the <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>, the planar diffusion coefficient (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) was computed as it can provide more specific information of the complexity of the neural structure. Our main finding indicated that adults with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> had higher mean <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> values than controls. A less complex neural structure in adults with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> could have explained the results, but no significant difference in <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> was found. Our results suggest that there are global abnormalities in the <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content> tissue of adults with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>. <jats:italic><jats:bold>Autism Res<\/jats:bold> 2013, 6: 642\u2013650.<\/jats:italic> \u00a9 2013 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/aur.1332","type":"journal-article","created":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T00:42:50Z","timestamp":1380760970000},"page":"642-650","source":"Crossref","is-referenced-by-count":21,"title":["Increased Coherence of White Matter Fiber Tract Organization in Adults with <scp>A<\/scp>sperger Syndrome: A Diffusion Tensor Imaging Study"],"prefix":"10.1002","volume":"6","author":[{"given":"Ulrika","family":"Roine","sequence":"first","affiliation":[{"name":"Brain and Mind Laboratory Department of Biomedical Engineering and Computational Science Aalto University  Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Roine","sequence":"additional","affiliation":[{"name":"iMinds\u2010Vision Lab, Department of Physics University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Salmi","sequence":"additional","affiliation":[{"name":"Brain and Mind Laboratory Department of Biomedical Engineering and Computational Science Aalto University  Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taina","family":"Nieminen\u2010Von Wendt","sequence":"additional","affiliation":[{"name":"Neuropsychiatric Rehabilitation and Medical Centre Neuromental  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Lepp\u00e4m\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Clinic for Neuropsychiatry Helsinki University Central Hospital  Helsinki Finland"},{"name":"Finnish Institute of Occupational Health  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pertti","family":"Rintahaka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Clinic for Neuropsychiatry Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka","family":"Tani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Clinic for Neuropsychiatry Helsinki University Central Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Leemans","sequence":"additional","affiliation":[{"name":"Image Sciences Institute, University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Sams","sequence":"additional","affiliation":[{"name":"Brain and Mind Laboratory Department of Biomedical Engineering and Computational Science 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