{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:35:23Z","timestamp":1790667323032,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T00:00:00Z","timestamp":1386806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Wellcome Trust","award":["GR045093MA"],"award-info":[{"award-number":["GR045093MA"]}]},{"name":"Department of Health","award":["039\/0026"],"award-info":[{"award-number":["039\/0026"]}]},{"DOI":"10.13039\/501100000363","name":"Remedi","doi-asserted-by":"crossref","award":["22"],"award-info":[{"award-number":["22"]}],"id":[{"id":"10.13039\/501100000363","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2014,6]]},"abstract":"Objective<\/jats:title>To test whether gut permeability is increased in autism spectrum disorders (ASD<\/jats:styled-content>) by evaluating gut permeability in a population\u2010derived cohort of children with ASD<\/jats:styled-content> compared with age\u2010 and intelligence quotient\u2010matched controls without ASD<\/jats:styled-content> but with special educational needs (SEN<\/jats:styled-content>).<\/jats:p><\/jats:sec>Patients and Methods<\/jats:title>One hundred thirty\u2010three children aged 10\u201314 years, 103 with ASD<\/jats:styled-content> and 30 with SEN<\/jats:styled-content>, were given an oral test dose of mannitol and lactulose and urine collected for 6\u2009hr. Gut permeability was assessed by measuring the urine lactulose\/mannitol (L\/M) recovery ratio by electrospray mass spectrometry\u2010mass spectrometry. The ASD<\/jats:styled-content> group was subcategorized for comparison into those without (n<\/jats:italic>\u2009=\u200983) and with (n<\/jats:italic>\u2009=\u200920) regression.<\/jats:p><\/jats:sec>Results<\/jats:title>There was no significant difference in L\/M recovery ratio (mean (95% confidence interval)) between the groups with ASD<\/jats:styled-content>: 0.015 (0.013\u20130.018), and SEN<\/jats:styled-content>: 0.014 (0.009\u20130.019), nor in lactulose, mannitol, or creatinine recovery. No significant differences were observed in any parameter for the regressed versus non\u2010regressed ASD<\/jats:styled-content> groups. Results were consistent with previously published normal ranges. Eleven children (9\/103\u2009=\u20098.7% ASD<\/jats:styled-content> and 2\/30\u2009=\u20096.7% SEN<\/jats:styled-content>) had L\/M recovery ratio >\u20090.03 (the accepted normal range cut\u2010off), of whom two (one ASD<\/jats:styled-content> and one SEN<\/jats:styled-content>) had more definitely pathological L\/M recovery ratios >\u20090.04.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>There is no statistically significant group difference in small intestine permeability in a population cohort\u2010derived group of children with ASD<\/jats:styled-content> compared with a control group with SEN<\/jats:styled-content>. Of the two children (one ASD<\/jats:styled-content> and one SEN<\/jats:styled-content>) with an L\/M recovery ratio of >\u20090.04, one had undiagnosed asymptomatic celiac disease (ASD<\/jats:styled-content>) and the other (SEN<\/jats:styled-content>) past extensive surgery for gastroschisis. Autism Res<\/jats:italic><\/jats:bold> 2014, 7: 305\u2013313.<\/jats:italic> \u00a9 2013 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/aur.1350","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T17:40:12Z","timestamp":1386870012000},"page":"305-313","source":"Crossref","is-referenced-by-count":41,"title":["Gut Permeability in Autism Spectrum Disorders"],"prefix":"10.1002","volume":"7","author":[{"given":"Neil","family":"Dalton","sequence":"first","affiliation":[{"name":"WellChild Laboratory Evelina Children's Hospital & King's College London London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susie","family":"Chandler","sequence":"additional","affiliation":[{"name":"Paediatric Neurosciences Newcomen Centre Guy's & St Thomas' NHS Foundation Trust London"},{"name":"King's College London Institute of Psychiatry 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