{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:28:32Z","timestamp":1772756912785,"version":"3.50.1"},"reference-count":73,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T00:00:00Z","timestamp":1401926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Research Council"},{"name":"AIMS Consortium","award":["G0400061"],"award-info":[{"award-number":["G0400061"]}]},{"name":"NIHR Biomedical Research Centre"},{"name":"South London & Maudsley NHS Foundation Trust"},{"name":"Innovative Medicines Initiative Joint Undertaking","award":["115300"],"award-info":[{"award-number":["115300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Autism Spectrum Disorder (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>) is diagnosed on the basis of behavioral symptoms, but cognitive abilities may also be useful in characterizing individuals with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>. One hundred seventy\u2010eight high\u2010functioning male adults, half with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> and half without, completed tasks assessing <jats:styled-content style=\"fixed-case\">IQ<\/jats:styled-content>, a broad range of cognitive skills, and autistic and comorbid symptomatology. The aims of the study were, first, to determine whether significant differences existed between cases and controls on cognitive tasks, and whether cognitive profiles, derived using a multivariate classification method with data from multiple cognitive tasks, could distinguish between the two groups. Second, to establish whether cognitive skill level was correlated with degree of autistic symptom severity, and third, whether cognitive skill level was correlated with degree of comorbid psychopathology. Fourth, cognitive characteristics of individuals with <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sperger Syndrome (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>) and high\u2010functioning autism (<jats:styled-content style=\"fixed-case\">HFA<\/jats:styled-content>) were compared. After controlling for <jats:styled-content style=\"fixed-case\">IQ<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> and control groups scored significantly differently on tasks of social cognition, motor performance, and executive function (<jats:italic>P<\/jats:italic>'s\u2009&lt;\u20090.05). To investigate cognitive profiles, 12 variables were entered into a support vector machine (<jats:styled-content style=\"fixed-case\">SVM<\/jats:styled-content>), which achieved good classification accuracy (81%) at a level significantly better than chance (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). After correcting for multiple correlations, there were no significant associations between cognitive performance and severity of either autistic or comorbid symptomatology. There were no significant differences between <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HFA<\/jats:styled-content> groups on the cognitive tasks. Cognitive classification models could be a useful aid to the diagnostic process when used in conjunction with other data sources\u2014including clinical history. <jats:bold><jats:italic>Autism Res<\/jats:italic><\/jats:bold> <jats:italic>2014, 7: 568\u2013581.<\/jats:italic> \u00a9 2014 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/aur.1394","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T17:59:04Z","timestamp":1401991144000},"page":"568-581","source":"Crossref","is-referenced-by-count":95,"title":["The Neuropsychology of Male Adults With High\u2010Functioning Autism or Asperger Syndrome"],"prefix":"10.1002","volume":"7","author":[{"given":"C. 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