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We report initial findings on whole and regional longitudinal brain development in 100 male participants with\n                    <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>\n                    (226 high\u2010quality magnetic resonance imaging [\n                    <jats:styled-content style=\"fixed-case\">MRI]<\/jats:styled-content>\n                    scans; mean inter\u2010scan interval 2.7 years) compared to 56 typically developing controls (\n                    <jats:styled-content style=\"fixed-case\">TDC<\/jats:styled-content>\n                    s) (117 high\u2010quality scans; mean inter\u2010scan interval 2.6 years) from childhood into adulthood, for a total of 156 participants scanned over an 8\u2010year period. This initial analysis includes between one and three high\u2010quality scans per participant that have been processed and segmented to date, with 21% having one scan, 27% with two scans, and 52% with three scans in the\n                    <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>\n                    sample; corresponding percentages for the\n                    <jats:styled-content style=\"fixed-case\">TDC<\/jats:styled-content>\n                    sample are 30%, 30%, and 40%. The proportion of participants with multiple scans (79% of\n                    <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>\n                    s and 68% of\n                    <jats:styled-content style=\"fixed-case\">TDC<\/jats:styled-content>\n                    s) was high in comparison to that of large longitudinal neuroimaging studies of typical development. We provide volumetric growth curves for the entire brain, total gray matter (\n                    <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>\n                    ), frontal\n                    <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>\n                    , temporal\n                    <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>\n                    , parietal\n                    <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>\n                    , occipital\n                    <jats:styled-content style=\"fixed-case\">GM<\/jats:styled-content>\n                    , total cortical white matter (\n                    <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>\n                    ), corpus callosum, caudate, thalamus, total cerebellum, and total ventricles. Mean volume of cortical\n                    <jats:styled-content style=\"fixed-case\">WM<\/jats:styled-content>\n                    was reduced significantly. Mean ventricular volume was increased in the\n                    <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>\n                    sample relative to the\n                    <jats:styled-content style=\"fixed-case\">TDC<\/jats:styled-content>\n                    s across the broad age range studied. Decreases in regional mean volumes in the\n                    <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>\n                    sample most often were due to decreases during late adolescence and adulthood. The growth curve of whole brain volume over time showed increased volumes in young children with autism, and subsequently decreased during adolescence to meet the\n                    <jats:styled-content style=\"fixed-case\">TDC<\/jats:styled-content>\n                    curve between 10 and 15 years of age. The volume of many structures continued to decline atypically into adulthood in the\n                    <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>\n                    sample. The data suggest that\n                    <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>\n                    is a dynamic disorder with complex changes in whole and regional brain volumes that change over time from childhood into adulthood.\n                    <jats:bold>\n                      <jats:italic>Autism Res<\/jats:italic>\n                    <\/jats:bold>\n                    <jats:italic>2015, 8: 82\u201393<\/jats:italic>\n                    . \u00a9 2014 International Society for Autism Research, Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/aur.1427","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T12:38:00Z","timestamp":1415363880000},"page":"82-93","source":"Crossref","is-referenced-by-count":221,"title":["Longitudinal Volumetric Brain Changes in Autism Spectrum Disorder Ages 6\u201335 Years"],"prefix":"10.1002","volume":"8","author":[{"given":"Nicholas","family":"Lange","sequence":"first","affiliation":[{"name":"Department of Psychiatry Harvard School of Medicine  Boston Massachusetts"},{"name":"Neurostatistics Laboratory McLean Hospital  Belmont Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany G.","family":"Travers","sequence":"additional","affiliation":[{"name":"Waisman Laboratory for Brain Imaging and Behavior University of Wisconsin  Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin D.","family":"Bigler","sequence":"additional","affiliation":[{"name":"Department of Psychology Brigham Young University  Provo Utah"},{"name":"Neuroscience Center Brigham Young University  Provo Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly B.D.","family":"Prigge","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah Primary Children's Medical Center  Salt Lake City Utah"},{"name":"Department of Radiology University of Utah  Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyson L.","family":"Froehlich","sequence":"additional","affiliation":[{"name":"Scientific Computing and Imaging Institute University of Utah  Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared A.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Interdepartmental Program in Neuroscience University of Utah  Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annahir N.","family":"Cariello","sequence":"additional","affiliation":[{"name":"Scientific Computing and Imaging Institute University of Utah  Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon A.","family":"Zielinski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah Primary Children's Medical Center  Salt Lake City Utah"},{"name":"Department of Neurology University of Utah  Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Utah  Salt Lake City Utah"},{"name":"Interdepartmental Program in Neuroscience University of Utah  Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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