{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:08:55Z","timestamp":1791234535469,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NIH","award":["T32 GM007223"],"award-info":[{"award-number":["T32 GM007223"]}]},{"name":"NIH","award":["F31 DC012270"],"award-info":[{"award-number":["F31 DC012270"]}]},{"name":"Manton Family Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Language and communication development is a complex process influenced by numerous environmental and genetic factors. Many neurodevelopment disorders include deficits in language and communication skills in their diagnostic criteria, including autism spectrum disorders (ASD<\/jats:styled-content>), language impairment (LI<\/jats:styled-content>), and dyslexia. These disorders are polygenic and complex with a significant genetic component contributing to each. The similarity of language phenotypes and comorbidity of these disorders suggest that they may share genetic contributors. To test this, we examined the association of genes previously implicated in dyslexia, LI<\/jats:styled-content>, and\/or language\u2010related traits with language skills in children with ASD<\/jats:styled-content>. We used genetic and language data collected in the A<\/jats:styled-content>utism G<\/jats:styled-content>enome R<\/jats:styled-content>esearch E<\/jats:styled-content>xchange (AGRE<\/jats:styled-content>) and S<\/jats:styled-content>imons S<\/jats:styled-content>implex C<\/jats:styled-content>ollection (SSC<\/jats:styled-content>) cohorts to perform a meta\u2010analysis on performance on a receptive vocabulary task. There were associations with LI<\/jats:styled-content> risk gene ATP2C2<\/jats:italic><\/jats:styled-content> and dyslexia risk gene MRPL19<\/jats:italic><\/jats:styled-content>. Additionally, we found suggestive evidence of association with CMIP<\/jats:italic><\/jats:styled-content>, GCFC2<\/jats:italic><\/jats:styled-content>, KIAA0319L<\/jats:italic><\/jats:styled-content>, the DYX<\/jats:styled-content>2 locus (ACOT13<\/jats:italic><\/jats:styled-content>, GPLD1<\/jats:italic><\/jats:styled-content>, and FAM65B<\/jats:italic><\/jats:styled-content>), and DRD2<\/jats:italic><\/jats:styled-content>. Our results show that LI<\/jats:styled-content> and dyslexia genes also contribute to language traits in children with ASD<\/jats:styled-content>. These associations add to the growing literature of generalist genes that contribute to multiple related neurobehavioral traits. Future studies should examine whether other genetic contributors may be shared among these disorders and how risk variants interact with each other and the environment to modify clinical presentations. Autism Res<\/jats:bold> 2015, 8: 229\u2013234<\/jats:italic>. \u00a9 2014 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/aur.1436","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T20:36:14Z","timestamp":1417466174000},"page":"229-234","source":"Crossref","is-referenced-by-count":39,"title":["Language Impairment and Dyslexia Genes Influence Language Skills in Children With Autism Spectrum Disorders"],"prefix":"10.1002","volume":"8","author":[{"given":"John D.","family":"Eicher","sequence":"first","affiliation":[{"name":"Department of Genetics Yale University New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Gruen","sequence":"additional","affiliation":[{"name":"Department of Genetics Yale University New Haven Connecticut"},{"name":"Departments of Pediatrics and Investigative Medicine Yale University School of Medicine New Haven 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