{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:48:20Z","timestamp":1790210900233,"version":"4.1.0"},"reference-count":77,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T00:00:00Z","timestamp":1423267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"publisher","award":["204340"],"award-info":[{"award-number":["204340"]}],"id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Mental Health Intramural Research Program"},{"name":"National Institutes of Health Pioneer Award"},{"name":"National Science Foundation","award":["IOS 1257768"],"award-info":[{"award-number":["IOS 1257768"]}]},{"name":"the Swiss National Science Foundation","award":["PBSKP3-123434 and PA00P3_134196"],"award-info":[{"award-number":["PBSKP3-123434 and PA00P3_134196"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>\n                    Recurrent deletions and duplications at chromosomal region 16p11.2 are variably associated with speech delay, autism spectrum disorder, developmental delay, schizophrenia, and cognitive impairments. Social communication deficits are a primary diagnostic symptom of autism. Here we investigated ultrasonic vocalizations (USVs) in young adult male 16p11.2 deletion mice during a novel three\u2010phase male\u2013female social interaction test that detects vocalizations emitted by a male in the presence of an estrous female, how the male changes its calling when the female is suddenly absent, and the extent to which calls resume when the female returns. Strikingly fewer vocalizations were detected in two independent cohorts of 16p11.2 heterozygous deletion males (+\/\u2212) during the first exposure to an unfamiliar estrous female, as compared to wildtype littermates (+\/+). When the female was removed, +\/+ emitted calls, but at a much lower level, whereas +\/\u2212 males called minimally. Sensory and motor abnormalities were detected in +\/\u2212, including higher nociceptive thresholds, a complete absence of acoustic startle responses, and hearing loss in all +\/\u2212 as confirmed by lack of auditory brainstem responses to frequencies between 8 and 100 kHz. Stereotyped circling and backflipping appeared in a small percentage of individuals, as previously reported. However, these sensory and motor phenotypes could not directly explain the low vocalizations in 16p11.2 deletion mice, since (a) +\/\u2212 males displayed normal abilities to emit vocalizations when the female was subsequently reintroduced, and (b) +\/\u2212 vocalized less than +\/+ to social odor cues delivered on an inanimate cotton swab. Our findings support the concept that mouse USVs in social settings represent a response to social cues, and that 16p11.2 deletion mice are deficient in their initial USVs responses to novel social cues.\n                    <jats:bold>\n                      <jats:italic>Autism Res<\/jats:italic>\n                    <\/jats:bold>\n                    <jats:italic>2015, 8: 507\u2013521<\/jats:italic>\n                    . \u00a9 2015 International Society for Autism Research, Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/aur.1465","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T00:41:55Z","timestamp":1423269715000},"page":"507-521","source":"Crossref","is-referenced-by-count":90,"title":["16p11.2 Deletion Syndrome Mice Display Sensory and Ultrasonic Vocalization Deficits During Social Interactions"],"prefix":"10.1002","volume":"8","author":[{"given":"Mu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California Davis School of Medicine Sacramento CA 95817"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena J.","family":"Mahrt","sequence":"additional","affiliation":[{"name":"School of Biological Sciences College of Arts and Sciences, Washington State University Vancouver Vancouver WA 98686"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freeman","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California Davis School of Medicine Sacramento CA 95817"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Foley","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California Davis School of Medicine Sacramento CA 95817"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Portmann","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Stanford University School of Medicine Stanford CA 94305"},{"name":"Drug Discovery Program Circuit Therapeutics Inc. 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