{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:07:48Z","timestamp":1790683668954,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,24]],"date-time":"2015-05-24T00:00:00Z","timestamp":1432425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"NICHD","award":["R21 HD065289"],"award-info":[{"award-number":["R21 HD065289"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>\n                    Children with autism spectrum disorder (ASD) may present with multiple medical conditions in addition to ASD symptoms. This study investigated whether there are predictive patterns of medical conditions that co\u2010occur with ASD, which could inform medical evaluation and treatment in ASD, as well as potentially identify etiologically meaningful subgroups. Medical history data were queried in the multiplex family Autism Genetic Resource Exchange (AGRE). Fourteen medical conditions were analyzed. Replication in the Simons Simplex Collection (SSC) was attempted using available medical condition data on gastrointestinal disturbances (GID), sleep problems, allergy and epilepsy. In the AGRE cohort, no discrete clusters emerged among 14 medical conditions. GID and seizures were enriched in unaffected family members, and together with sleep problems, were represented in both AGRE and SSC. Further analysis of these medical conditions identified predictive co\u2010occurring patterns in both samples. For a child with ASD, the presence of GID predicts sleep problems and vice versa, with an approximately 2\u2010fold odds ratio in each direction. These risk patterns were replicated in the SSC sample, and in addition, there was increased risk for seizures and sleep problems to co\u2010occur with GID. In these cohorts, seizure alone was not predictive of the other conditions co\u2010occurring, but behavioral impairments were more severe as the number of co\u2010occurring medical symptoms increased. These findings indicate that interdisciplinary clinical care for children with ASD will benefit from evaluation for specific patterns of medical conditions in the affected child and their family members.\n                    <jats:bold>\n                      <jats:italic>Autism Res<\/jats:italic>\n                    <\/jats:bold>\n                    <jats:italic>2015, 8: 771\u2013781<\/jats:italic>\n                    . \u00a9 015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research.\n                  <\/jats:p>","DOI":"10.1002\/aur.1492","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T10:22:18Z","timestamp":1432549338000},"page":"771-781","source":"Crossref","is-referenced-by-count":122,"title":["Patterns of Risk for Multiple Co\u2010Occurring Medical Conditions Replicate Across Distinct Cohorts of Children with Autism Spectrum 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California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat","family":"Levitt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Keck School of Medicine, University of Southern California Los Angeles 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