{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:37:54Z","timestamp":1775918274853,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T00:00:00Z","timestamp":1458518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["LP110200562"],"award-info":[{"award-number":["LP110200562"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1061922"],"award-info":[{"award-number":["1061922"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FL0992409"],"award-info":[{"award-number":["FL0992409"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Autism spectrum disorder (ASD) is a group of heterogeneous neurodevelopmental conditions associated with persistent, stereotyped or repetitive actions, and patterns of interest that are maintained in spite of possible negative outcomes. The aim of the present study was to investigate whether impairments in the ability to execute flexible goal\u2010directed actions may be an underlying feature in ASD contributing to these symptoms. Young adults diagnosed with ASD were recruited along with controls and adults with social anxiety disorder (SAD). Participants were trained to make keyboard actions for food outcomes and then subsequently allowed to consume one outcome till satiety. As expected, this outcome devaluation procedure reduced subsequent responding for actions predicting the devalued outcome, while maintaining responding on the other still\u2010valued action, in controls. However, both ASD and SAD participants were unable to demonstrate flexible goal\u2010directed actions, and were insensitive to the change in outcome value on subsequent action control. This behavioral deficit was not due to impairments in appropriate contingency awareness, as all groups rated the devalued food outcome as less pleasant after devaluation. A lack of control over actions may underlie persistent and habitual actions in anxiety\u2010inducing contexts typical in both ASD and SAD, such as avoidance and safety behaviors. Using a translational behavioral paradigm, this study demonstrated that individuals with ASD are unable to use changes in the environment to flexibly update their behavior in the same context. This reduced behavioral control may underlie persistence of intrusive actions and restricted inflexible cognition, representing a specific area for targeted behavioral interventions. <jats:italic><jats:bold>Autism Res<\/jats:bold> 2016<\/jats:italic>. \u00a9 2016 International Society for Autism Research, Wiley Periodicals, Inc. <jats:bold><jats:italic>Autism Res<\/jats:italic><\/jats:bold> <jats:italic>2016, 9: 1285\u20131293<\/jats:italic>. \u00a9 2016 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/aur.1613","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T02:29:12Z","timestamp":1458613752000},"page":"1285-1293","source":"Crossref","is-referenced-by-count":43,"title":["Reduced goal\u2010directed action control in autism spectrum disorder"],"prefix":"10.1002","volume":"9","author":[{"given":"Gail A.","family":"Alvares","sequence":"first","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney Sydney NSW Australia"},{"name":"Telethon Kids Institute, The University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard W.","family":"Balleine","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Whittle","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam J.","family":"Guastella","sequence":"additional","affiliation":[{"name":"Brain and Mind Centre, The University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14640748108400816"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094778"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.10.2.176"},{"key":"e_1_2_6_5_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"APA","year":"2000"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.07.002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(98)00033-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.131"},{"key":"e_1_2_6_9_1","volume-title":"Anxiety disorders interview schedule adult version (ADIS\u2010IV)","author":"Brown T.","year":"1994"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-4-31"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7893.2012.00364.x"},{"key":"e_1_2_6_12_1","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-11-04563.2002"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0031721"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00963-7"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2010.21514"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1639-09.2009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1088-12.2012"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.10.029"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03199951"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471214426.pas0312"},{"key":"e_1_2_6_22_1","volume-title":"User's guide for the structured clinical interview for DSM\u2010IV axis I disorders SCID\u2010I: Clinician version","author":"First M.B.","year":"1997"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700049163"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361313477919"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2008.11.006"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.10071062"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-008-0674-3"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2014.00101"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/17470218.2010.518242"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2012.02.016"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.03.040"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-5-200703060-00004"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2011.05.018"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03395600"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02172145"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005592401947"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.06.005"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(81)90310-3"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0979-09.2009"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(99)00020-2"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-6-57"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1255"},{"key":"e_1_2_6_44_1","volume-title":"STAI manual for the State\u2010Trait Anxiety Inventory (\u201cself\u2010evaluation questionnaire\u201d)","author":"Spielberger C.D.","year":"1970"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06796.x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0564-07.2007"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-006-0092-3"}],"container-title":["Autism Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Faur.1613","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Faur.1613","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.1613","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/aur.1613","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/aur.1613","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.1613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T10:26:43Z","timestamp":1696588003000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aur.1613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,21]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1002\/aur.1613"],"URL":"https:\/\/doi.org\/10.1002\/aur.1613","archive":["Portico"],"relation":{},"ISSN":["1939-3792","1939-3806"],"issn-type":[{"value":"1939-3792","type":"print"},{"value":"1939-3806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,21]]}}}