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BTBR T+tf\/J (BTBR) is an inbred mouse strain that exhibits prominent behavioral phenotypes with face validity to all three diagnostic symptom categories of autism, including robust and well\u2010replicated deficits in social approach and reciprocal social interactions. To investigate the role of peer interactions in the development of sociability, BTBR juvenile mice were reared in the same home cage with juvenile mice of a highly social inbred strain, C57BL\/6J (B6). Subject mice were tested as young adults for sociability and repetitive behaviors. B6 controls reared with B6 showed their strain\u2010typical high sociability. BTBR controls reared with BTBR showed their strain\u2010typical lack of sociability. In contrast, BTBR reared with B6 as juveniles showed significant sociability as young adults. A 20\u2010day intervention was as effective as a 40\u2010day intervention for improving social approach behavior. High levels of repetitive self\u2010grooming in BTBR were not rescued by peer\u2010rearing with B6, indicating specificity of the intervention to the social domain. These results from a robust mouse model of autism support the interpretation that social enrichment with juvenile peers is a beneficial intervention for improving adult outcome in the social domain. This novel paradigm may prove useful for discovering factors that are essential for effective behavioral treatments, and biological mechanisms underlying effective behavioral interventions.<\/jats:p>","DOI":"10.1002\/aur.163","type":"journal-article","created":{"date-parts":[[2010,10,6]],"date-time":"2010-10-06T18:27:25Z","timestamp":1286389645000},"page":"17-27","source":"Crossref","is-referenced-by-count":89,"title":["Social peers rescue autism\u2010relevant sociability deficits in adolescent mice"],"prefix":"10.1002","volume":"4","author":[{"given":"Mu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam 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