{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:51:29Z","timestamp":1792662689323,"version":"4.5.0"},"reference-count":66,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T00:00:00Z","timestamp":1464134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>Group B <jats:italic>Streptococcus<\/jats:italic> (GBS) is a commensal bacterium present in the lower genital tract of 15\u201330% of healthy pregnant women. GBS is the leading cause of chorioamnionitis and cerebral injuries in newborns, occurring most often in the absence of maternofetal pathogen translocation. Despite GBS being the most frequent bacterium colonizing pregnant women, no preclinical studies have investigated the impact of end\u2010gestational maternal GBS exposure on the offspring's brain development and its behavioral correlates. Our hypothesis is that GBS\u2010induced gestational infection\/inflammation has a deleterious neurodevelopmental impact on uninfected offspring. Our goal was to study the impact of maternal GBS infection on the placental and neurodevelopmental features in the offspring using a new preclinical rat model. GBS\u2010exposed placentas exhibited chorioamnionitis characterized by the presence of Gram\u2010positive cocci and polymorphonuclear cells, with the latter being significantly more prominent in the labyrinth of male offspring. GBS\u2010exposed male offspring had reduced thickness of periventricular white matter. In addition, they exhibited autistic\u2010like behaviors, such as abnormal social interaction and communication, impaired processing of sensory information and hyperactivity. Overall, these data show for the first time that gestational exposure to GBS plays an important role in the generation of neurodevelopmental abnormalities reminiscent of human autism spectrum disorders (ASD). These results provide new evidence in favor of the role of a common and modifiable infectious\/inflammatory environmental factor in human ASD pathophysiology. <jats:bold><jats:italic>Autism Res<\/jats:italic><\/jats:bold> <jats:italic>2017, 10: 233\u2013245<\/jats:italic>. \u00a9 2016 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/aur.1647","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T11:29:23Z","timestamp":1464175763000},"page":"233-245","source":"Crossref","is-referenced-by-count":41,"title":["A sexually dichotomous, autistic\u2010like phenotype is induced by Group B <i>Streptococcus<\/i> maternofetal immune activation"],"prefix":"10.1002","volume":"10","author":[{"given":"Marie\u2010Julie","family":"Allard","sequence":"first","affiliation":[{"name":"Department of Pediatrics Research Institute of the McGill University Health Centre, McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie D.","family":"Bergeron","sequence":"additional","affiliation":[{"name":"D\u00e9partement de P\u00e9diatrie Universit\u00e9 de Sherbrooke Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moogeh","family":"Baharnoori","sequence":"additional","affiliation":[{"name":"Division of Neurology University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit K.","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Douglas Mental Health University Institute, McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis\u2010Charles","family":"Fortier","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie et d'Infectiologie Universit\u00e9 de Sherbrooke Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Poyart","sequence":"additional","affiliation":[{"name":"INSERM U 1016, Institut Cochin, Team Barriers and Pathogens; DHU Risques et grossesse, H\u00f4pitaux Universitaire Paris Centre, Universit\u00e9 Paris Descartes Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"S\u00e9bire","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Research Institute of the McGill University Health Centre, McGill University Montreal Quebec Canada"},{"name":"D\u00e9partement de P\u00e9diatrie Universit\u00e9 de Sherbrooke Sherbrooke Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.09.003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2014.08.009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2014.10.014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2012.00046"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1107"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbq098"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2008.10.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmod.2005.05.004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355656"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.03.005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-55"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22024"},{"key":"e_1_2_6_14_1","first-page":"1","article-title":"Prevalence of autism spectrum disorder among children aged 8 years \u2013 Autism and developmental disabilities monitoring network, 11 sites, United States, 2010","volume":"63","author":"Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators, Centers for Disease Control and Prevention (CDC)","year":"2014","journal-title":"MMWR Surveill Summ"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1550-8579(07)80004-0"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S57057"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2014.04.001"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31819e7203"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/412831"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3039"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.07.003"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.09.001"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903349"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.01.008"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(71)90208-3"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.10.053"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22043"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.9.6149"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1586\/eci.11.51"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2013-0186"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-336"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.040"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.684165"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082244"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000290040"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.09.021"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.11.030"},{"key":"e_1_2_6_38_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1176\/jnp.2008.20.4.409","article-title":"The differential diagnosis of childhood\u2010 and young adult\u2010onset disorders that include psychosis","volume":"20","author":"Lauterbach M.D.","year":"2008","journal-title":"Journal of Neuropsychiatry Clinical Neurosciences"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674371005501105"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.09.001"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181bf5fab"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2158"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.01.011"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2009.10.018"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.01.009"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.05.001"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200201)46:1<250::AID-ART10064>3.0.CO;2-T"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1424-08.2008"},{"key":"e_1_2_6_49_1","first-page":"59","article-title":"Effect of clinical and histological chorioamnionitis on the outcome of preterm infants","volume":"30","author":"Nasef N.","year":"2013","journal-title":"American Journal of Perinatology"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.28.021406.144007"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.17.2056"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebn.11.4.122"},{"key":"e_1_2_6_53_1","first-page":"28","article-title":"Types and functions of ultrasonic vocalizations in laboratory rats and mice","volume":"46","author":"Portfors C.V.","year":"2007","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu067"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-012-1713-7"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.05.001"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300518"},{"key":"e_1_2_6_58_1","unstructured":"Sengupta P.(2013). The laboratory rat: relating its age with human's. International Journal of Preventive Medicine4 624\u2013630."},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-01-00297.2003"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm001"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2178-07.2007"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3217"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/2042-6410-3-15"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10110"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00673.x"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104433"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2257-10.2010"}],"container-title":["Autism Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Faur.1647","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Faur.1647","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.1647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:36:17Z","timestamp":1696606577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aur.1647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,25]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1002\/aur.1647"],"URL":"https:\/\/doi.org\/10.1002\/aur.1647","archive":["Portico"],"relation":{},"ISSN":["1939-3792","1939-3806"],"issn-type":[{"value":"1939-3792","type":"print"},{"value":"1939-3806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,25]]}}}