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Some of the earliest signs of ASD involve auditory processing, and a recent study found that hearing thresholds in children with ASD in the mid\u2010range frequencies were significantly related to receptive and expressive language measures. In addition, otoacoustic emissions have been used to detect reduced cochlear function in the presence of normal audiometric thresholds. We were interested then to know if otoacoustic emissions in children with normal audiometric thresholds would also reveal differences between children with ASD and typical developing (TD) controls in mid\u2010frequency regions. Our objective was to specifically measure baseline afferent otoacoustic emissions (distortion\u2010product otoacoustic emissions [DPOAEs]), transient\u2010evoked otoacoustic emissions (TrOAEs), and efferent suppression, in 35 children with high\u2010functioning ASD compared with 42 aged\u2010matched TD controls. All participants were males 6\u201317 years old, with normal audiometry, and rigorously characterized via Autism Diagnostic Interview\u2010Revised and Autism Diagnostic Observation Schedule. Children with ASD had greatly reduced DPOAE responses in the 1 kHz frequency range, yet had comparable DPOAE responses at 0.5 and 4\u20138 kHz regions. Furthermore, analysis of the spectral features of TrOAEs revealed significantly decreased emissions in ASD in similar frequencies. No significant differences were noted in DPOAE or TrOAE noise floors, middle ear muscle reflex activity, or efferent suppression between children with ASD and TD controls. In conclusion, attention to specific\u2010frequency deficits using non\u2010invasive measures of cochlear function may be important in auditory processing impairments found in ASD. <jats:bold><jats:italic>Autism Res<\/jats:italic><\/jats:bold> <jats:italic>2017, 10: 337\u2013345<\/jats:italic>. \u00a9 2016 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/aur.1663","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T13:52:55Z","timestamp":1468331575000},"page":"337-345","source":"Crossref","is-referenced-by-count":37,"title":["Children with autism spectrum disorder have reduced otoacoustic emissions at the 1 kHz mid\u2010frequency region"],"prefix":"10.1002","volume":"10","author":[{"given":"Loisa","family":"Bennetto","sequence":"first","affiliation":[{"name":"Department of Clinical and Social Sciences in Psychology University of Rochester Rochester New 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