{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:09:15Z","timestamp":1790428155771,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,11]],"date-time":"2018-02-11T00:00:00Z","timestamp":1518307200000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2017,2,11]],"date-time":"2017-02-11T00:00:00Z","timestamp":1486771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["5R21HD075971"],"award-info":[{"award-number":["5R21HD075971"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CBET\u20101507066"],"award-info":[{"award-number":["CBET\u20101507066"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>The purpose of this study was to investigate pupillary light reflex (PLR) in 2\u20136\u2010years\u2010old children with autism spectrum disorders (ASD). A total of 117 medication\u2010free 2\u20136\u2010year\u2010old boys participated in this study. Sixty participants were diagnosed with ASD (the \u201cASD group\u201d) and the other 57 were in the control group of typical development (the \u201cTD group\u201d). A questionnaire was completed by the parent\/guardian for assessing potential dysfunctions in the autonomic nervous system (ANS). The base pupil radius, PLR latency, and constriction time showed a significant age\u2010related trend in both the ASD and TD groups. The base pupil size increased with age in the typically developing children, but not in the ASD group. The ASD group showed more symptoms related to ANS dysfunctions. An association between abnormal sweating with base pupil radius and PLR constriction was observed in the TD group but not the ASD group. The different association of PLR parameters with ANS dysfunction may suggest disrupted autonomic controls in children with ASD. <jats:italic><jats:bold>Autism Res<\/jats:bold> 2017, 10: 829\u2013838<\/jats:italic>. \u00a9 2017 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/aur.1745","type":"journal-article","created":{"date-parts":[[2017,2,11]],"date-time":"2017-02-11T08:26:41Z","timestamp":1486801601000},"page":"829-838","source":"Crossref","is-referenced-by-count":30,"title":["Atypical pupillary light reflex in 2\u20136\u2010year\u2010old children with autism spectrum disorders"],"prefix":"10.1002","volume":"10","author":[{"given":"Dinalankara M. 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Miles J.H. Christ S.E. Beversdorf D.Q. Lofgreen A. Berliner N. \u2026Yao G.(2012). Age\u2010dependent pupillary light reflex parameters in children. 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