{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:42:36Z","timestamp":1792176156016,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>To determine whether children with autism spectrum disorders (ASDs) have an increased number of wave I abnormal amplitudes in auditory brainstem responses (ABRs) than age\u2010 and sex\u2010matched typically developing children. This analytical case\u2013control study compared patients with ASDs between the ages of 2 and 6 years and children who had a language delay not associated with any other pathology. Amplitudes of ABR waves I and V; absolute latencies (ALs) of waves I, III, and V; and interpeak latencies (IPLs) I\u2013III, III\u2013IV, and I\u2013V at 90 dB were compared between ASD patients and normally developing children. The study enrolled 40 children with documented ASDs and 40 age\u2010 and sex\u2010matched control subjects. Analyses of the ABR showed that children with ASDs exhibited higher amplitudes of wave 1 than wave V (35%) more frequently than the control group (10%), and this difference between groups reached statistical significance by Chi\u2010squared analysis. There were no significant differences in ALs and IPLs between ASD children and matched controls. To the best of our knowledge, this is the first case\u2013control study testing the amplitudes of ABR wave I in ASD children. The reported results suggest a potential for the use of ABR recordings in children, not only for the clinical assessment of hearing status, but also for the possibility of using amplitude of ABR wave I as an early marker of ASDs allowing earlier diagnosis and intervention.  <jats:bold><jats:italic>Autism Res<\/jats:italic><\/jats:bold> <jats:italic>2017<\/jats:italic>. \u00a9 2017 International Society for Autism Research, Wiley Periodicals, Inc. <jats:italic><jats:bold>Autism Res<\/jats:bold> 2017, 10: 1300\u20131305<\/jats:italic>. \u00a9 2017 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/aur.1771","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T02:01:44Z","timestamp":1491271304000},"page":"1300-1305","source":"Crossref","is-referenced-by-count":38,"title":["Autism spectrum disorders and the amplitude of auditory brainstem response wave I"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7041-0994","authenticated-orcid":false,"given":"Mariline","family":"Santos","sequence":"first","affiliation":[{"name":"Centro Hospitalar do Porto, Portugal, Largo do Prof. Albel Salazar 4099\u2010001 Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Marques","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto, Portugal, Largo do Prof. Albel Salazar 4099\u2010001 Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"N\u00f3brega Pinto","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto, Portugal, Largo do Prof. Albel Salazar 4099\u2010001 Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto, Portugal, Largo do Prof. Albel Salazar 4099\u2010001 Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Bebiano","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto, Portugal, Largo do Prof. Albel Salazar 4099\u2010001 Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cec\u00edlia","family":"Almeida e Sousa","sequence":"additional","affiliation":[{"name":"Centro Hospitalar do Porto, Portugal, Largo do Prof. Albel Salazar 4099\u2010001 Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.9.2145"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2779(2000)6:4<300::AID-MRDD9>3.0.CO;2-R"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2011.12.009"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2013.02.006"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(85)90967-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(02)00211-2"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0958"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90201-H"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31819e7203"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9450.2007.00597.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00046.2006"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.29-3-86"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2361"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001165"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.11.1077"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.160.5.659"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1561"},{"key":"e_1_2_5_19_1","unstructured":"Morbidity and Mortality Weekly report Surveillance Summary. (2012). Prevalence of autism spectrum disorders \u2013 autism and developmental disabilities monitoring network 14 sites United States 2008. Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators; Centers for Disease Control and Prevention (CDC) 61 1\u201324."},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.10.015"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2014.07.001"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2"},{"key":"e_1_2_5_23_1","first-page":"1403","article-title":"Auditory brainstem responses in pervasive developmental disorders","volume":"19","author":"Rumsey J.M.","year":"1984","journal-title":"Biological Psychiatry"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-6410(01)00045-3"},{"key":"e_1_2_5_25_1","doi-asserted-by":"crossref","first-page":"9529","DOI":"10.1523\/JNEUROSCI.18-22-09529.1998","article-title":"Serotonin modulation of sensory inputs to the lateral amygdala: dependency on corticosterone","volume":"18","author":"Stutzmann G.E.","year":"1998","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1982.04290020040008"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100044346"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2482-4"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.147.12.1609"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02207329"}],"container-title":["Autism Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Faur.1771","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.1771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:33:17Z","timestamp":1695540797000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aur.1771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/aur.1771"],"URL":"https:\/\/doi.org\/10.1002\/aur.1771","archive":["Portico"],"relation":{},"ISSN":["1939-3792","1939-3806"],"issn-type":[{"value":"1939-3792","type":"print"},{"value":"1939-3806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}