{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:54:07Z","timestamp":1791323647207,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T00:00:00Z","timestamp":1488931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004866","name":"National Research Program for Biopharmaceuticals","doi-asserted-by":"publisher","award":["MOST 104\u20102325\u2010B\u2010002\u2010032"],"award-info":[{"award-number":["MOST 104\u20102325\u2010B\u2010002\u2010032"]}],"id":[{"id":"10.13039\/501100004866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Individuals with Rett syndrome (RTT) can have variable manifestations of stereotypies. In this nation\u2010wide cross\u2010sectional study, we recruited all individuals with RTT in Taiwan diagnosed as RTT by neurologists based on genetic findings and diagnostic criteria. The data were collected using questionnaire. A total 43 cases of typical RTT and 15 cases of atypical RTT, aged from 2.1 to 40.1 years, were enrolled. They included 3 (5.2%) in stage II, 42 (72.4%) in stage III, and 13 (22.4%) in stage IV. All individuals presented with at least one stereotypy. Individuals with atypical RTT had more varied stereotypies (mean: 14\u2009\u00b1\u20096) compared to those with typical RTT (mean: 9\u2009\u00b1\u20095) (<jats:italic>P<\/jats:italic>\u2009=\u20090.003). Flapping (73.3%) and wringing (58.1%) were the most common hand stereotypies in atypical and typical RTT, respectively. Compared with typical RTT, hair pulling, bruxism, retropulsion, and protrusion of lips were more common in atypical RTT (<jats:italic>P<\/jats:italic>\u2009=\u20090.003, <jats:italic>P<\/jats:italic>\u2009=\u20090.006, <jats:italic>P<\/jats:italic>\u2009=\u20090.003 and &lt;0.001, respectively). The number of stereotypies did not differ among different stages, clinical severities, and hand functions. Although there were no age\u2010related changes in stereotypies in atypical RTT, flapping (<jats:italic>P<\/jats:italic>\u2009=\u20090.012), clapping (<jats:italic>P<\/jats:italic>\u2009=\u20090.044), and mouthing with single hand (<jats:italic>P<\/jats:italic>\u2009=\u20090.009) were significantly more prevalent in individuals aged &lt;10 years with typical RTT, and they decreased after 10 years. In conclusion, our study showed that the stereotypical movements varied in typical and atypical RTT, implying the heterogeneous nature of the disease and the pathogenic mechanisms of RTT with atypical features. <jats:bold><jats:italic>Autism Res<\/jats:italic><\/jats:bold> <jats:italic>2017<\/jats:italic>. \u00a9 2017 International Society for Autism Research, Wiley Periodicals, Inc. <jats:italic><jats:bold>Autism Res<\/jats:bold> 2017, 10: 1204\u20131214<\/jats:italic>. \u00a9 2017 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/aur.1774","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T10:38:41Z","timestamp":1488969521000},"page":"1204-1214","source":"Crossref","is-referenced-by-count":20,"title":["Variations of stereotypies in individuals with Rett syndrome: A nationwide cross\u2010sectional study in Taiwan"],"prefix":"10.1002","volume":"10","author":[{"given":"Lee","family":"Chin Wong","sequence":"first","affiliation":[{"name":"Department of Pediatrics Min\u2010Sheng General Hospital Min\u2010Sheng Hospital 168, ChingKuo Road Taoyuan 330 Taiwan"},{"name":"Department of Pediatric Neurology National Taiwan University Children's Hospital No8, Chung\u2010Shan South Road, Zhong\u2010Zheng District Taipei 100 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pi\u2010Lien","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kaohsiung Chang Gung Memorial Hospital No.123,DAPI Road, Niaosng District Kaohsiung 83301 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tz\u2010Yun","family":"Jan","sequence":"additional","affiliation":[{"name":"Graduate Institute of Brain and Mind Sciences, National Taiwan University No.1, Sec.1, Ren\u2010Ai Road Taipei 100 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