{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:01:53Z","timestamp":1789948913643,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:00:00Z","timestamp":1493942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Health Resources and Services Administration, Maternal and Child Health Research Program","award":["UA3 MC 11054"],"award-info":[{"award-number":["UA3 MC 11054"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>Children with Autism Spectrum Disorders (ASD) may be characterized as \u201ccomplex\u201d (those with microcephaly and\/or dysmorphology) or \u201cessential\u201d (those with neither of these two). Previous studies found subjects in the complex group exhibited lower IQ scores, poorer response to behavioral intervention, more seizures and more abnormal EEGs and brain MRIs compared to the essential group. The objective of this study was to determine if there are differences in complex versus essential subjects based on several developmental\/psychological measures as well as certain medical comorbidities. This study utilized data from 1,347 individuals (2\u201317 years old) well\u2010characterized subjects enrolled in Autism Treatment Network (ATN) Registry. Head circumference measurement and the Autism Dysmorphology Measure (ADM) were used by trained physicians to classify subjects as complex or essential. Significantly lower scores were seen for complex subjects in cognitive level, adaptive behavior and quality of life. Complex subjects showed significantly increased physician\u2010documented GI symptoms and were on a higher number of medications. No significant differences in autism severity scores, behavioral ratings and parent\u2010reported sleep problems were found. After adjusting for multiple comparisons made, adaptive scores remained significantly lower for the complex group, and the complex group used a significantly higher number of medications and had increased GI symptoms. Complex and essential autism subtypes may have distinct developmental and medical correlates and thus underlines the importance of looking for microcephaly and dysmorphology, when evaluating a child with autism. Determining this distinction in autism may have implications in prognosis, identifying medical co\u2010morbidities, directing diagnostic evaluations and treatment interventions. <jats:bold><jats:italic>Autism Res<\/jats:italic><\/jats:bold> <jats:italic>2017, 10: 1344\u20131352<\/jats:italic>. \u00a9 2017 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/aur.1779","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T06:36:49Z","timestamp":1493966209000},"page":"1344-1352","source":"Crossref","is-referenced-by-count":11,"title":["Developmental functioning and medical Co\u2010morbidity profile of children with complex and essential autism"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4635-7326","authenticated-orcid":false,"given":"Jaimie","family":"Flor","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Arkansas for Medical Sciences Little Rock AR"},{"name":"Biostatistics Center, Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayne","family":"Bellando","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Arkansas for Medical Sciences Little Rock AR"},{"name":"Biostatistics Center, Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Arkansas for Medical Sciences Little Rock AR"},{"name":"Biostatistics Center, Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Shui","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Arkansas for Medical Sciences Little Rock AR"},{"name":"Biostatistics Center, Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.21.8.265"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-2-15"},{"key":"e_1_2_7_4_1","volume-title":"Diagnostic and statistical manual of mental disorders","year":"2000"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361310397620"},{"key":"e_1_2_7_6_1","unstructured":"Autism Speaks. 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