{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:09:18Z","timestamp":1789715358432,"version":"4.0.1"},"reference-count":86,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Norway","award":["NF-CZ11-PDP-3-003-2014"],"award-info":[{"award-number":["NF-CZ11-PDP-3-003-2014"]}]},{"name":"Faculty of Medicine, Charles University","award":["(No. LM2015091)"],"award-info":[{"award-number":["(No. LM2015091)"]}]},{"name":"Faculty Hosp. 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An unbiased, automatable, computational workflow interaction model was developed using available data from public databases. The interaction network model of ASD\u2010associated genes with known cerebral expression and function (SFARI) and metabolic networks (MetScape), including connections to known metabolic substrates, metabolites and cofactors involving folates, was established. Intersection of bioinformatically created networks resulted in a limited amount of interaction modules pointing to common disturbed metabolic pathways, linking ASD to CFD. Two independent interaction modules (comprising three pathways) covering enzymes encoded by ASD\u2010related genes and folate cofactors utilizing enzymes were generated. Module 1 suggested possible interference of CFD with serine and lysine metabolism, while module 2 identified correlations with purine metabolism and inosine monophosphate production. Since our approach was primarily conceived as a proof of principle, further amendments of the presented initial model are necessary to obtain additional actionable outcomes. Our modelling strategy identified not only previously known interactions supported by evidence\u2010based analyses, but also novel plausible interactions, which could be validated in subsequent functional and\/or clinical studies.\n                    <jats:bold>\n                      <jats:italic>Autism Res<\/jats:italic>\n                    <\/jats:bold>\n                    <jats:italic>2017, 10: 1424\u20131435<\/jats:italic>\n                    . \u00a9 2017 International Society for Autism Research, Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/aur.1780","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T03:52:50Z","timestamp":1490413970000},"page":"1424-1435","source":"Crossref","is-referenced-by-count":12,"title":["Identification of likely associations between cerebral folate deficiency and complex genetic\u2010 and metabolic pathogenesis of autism spectrum disorders by utilization of a pilot interaction modeling approach"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7157-9716","authenticated-orcid":false,"given":"Daniel","family":"Krsi\u010dka","sequence":"first","affiliation":[{"name":"Department of Biology and Medical Genetics, 2nd Faculty of Medicine Charles University and University Hospital Motol V \u00davalu 84, 150 06 Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Geryk","sequence":"additional","affiliation":[{"name":"Department of Biology and Medical Genetics, 2nd Faculty of Medicine Charles University and University Hospital Motol V \u00davalu 84, 150 06 Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u00e9ta","family":"Vl\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Biology and Medical Genetics, 2nd Faculty of Medicine Charles University and University Hospital Motol V \u00davalu 84, 150 06 Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u00e9ta","family":"Havlovicov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Biology and Medical Genetics, 2nd Faculty of Medicine Charles University and University Hospital Motol V \u00davalu 84, 150 06 Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Milan","family":"Macek","sequence":"additional","affiliation":[{"name":"Department of Biology and Medical Genetics, 2nd Faculty of Medicine Charles University and University Hospital Motol V \u00davalu 84, 150 06 Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radka","family":"Pourov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Biology and Medical Genetics, 2nd Faculty of Medicine Charles University and University Hospital Motol V \u00davalu 84, 150 06 Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-4-36"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.05.025"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","unstructured":"Akiyama T. 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