{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:59:36Z","timestamp":1789988376294,"version":"4.0.1"},"reference-count":97,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T00:00:00Z","timestamp":1295395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Elevated whole blood serotonin 5\u2010HT, or hyperserotonemia, is a common biomarker in autism spectrum disorder (ASD). The integrin \u03b23 receptor subunit gene (<jats:italic>ITGB3<\/jats:italic>) is a quantitative trait locus for whole blood 5\u2010HT levels. Recent work shows that integrin \u03b23 interacts with the serotonin transporter (SERT) in both platelets and in the midbrain. Furthermore, multiple studies have now reported gene\u2013gene interaction between the integrin \u03b23 and SERT genes in association with ASD. Given the lack of previous data on the impact of integrin \u03b23 on brain or behavioral phenotypes, we sought to compare mice with decreased or absent expression of the integrin \u03b23 receptor subunit (<jats:italic>Itgb3<\/jats:italic> + \/ \u2212 and \u2212\/ \u2212) with wildtype littermate controls in behavioral tasks relevant to ASD. These mice did not show deficits in activity level in the open field or anxiety\u2010like behavior on the elevated plus maze, two potential confounds in the evaluation of mouse social behavior. In the three\u2010chamber social test, mice lacking integrin \u03b23 were shown to have normal sociability but did not show a preference for social novelty. Importantly, the absence of integrin \u03b23 did not impair olfaction or the ability to recall familiar social odors. Additionally, mice lacking integrin \u03b23 showed increased grooming behavior in novel environments. These preliminary studies reveal altered social and repetitive behavior in these mice, which suggests that the integrin \u03b23 subunit may be involved in brain systems relevant to ASD. Further work is needed to fully characterize these behavioral changes and the underlying brain mechanisms.<\/jats:p>","DOI":"10.1002\/aur.180","type":"journal-article","created":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T19:05:30Z","timestamp":1295463930000},"page":"57-67","source":"Crossref","is-referenced-by-count":102,"title":["Absence of preference for social novelty and increased grooming in integrin \u03b23 knockout mice: Initial studies and future directions"],"prefix":"10.1002","volume":"4","author":[{"given":"Michelle D.","family":"Carter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charisma R.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline N.","family":"Crawley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M. D.","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Veenstra\u2010VanderWeele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/320112"},{"key":"e_1_2_6_3_1","first-page":"36","article-title":"Image Processing with ImageJ","volume":"11","author":"Abramoff M.D.","year":"2004","journal-title":"Biophotonics International"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02212938"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.60.110707.163514"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90568-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700028099"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.589"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4517-09.2010"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2009.06.003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.12.2148"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.31887\/DCNS.2009.11.1\/jdbuxbaum","article-title":"Multiple rare variants in the etiology of autism spectrum disorders","volume":"11","author":"Buxbaum J.D.","year":"2009","journal-title":"Dialogues in Clinical Neurosciences"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI33374"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.22"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.24.3093"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/35077101"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.055"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1740925X0999024X"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.5.524"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-199608000-00008"},{"key":"e_1_2_6_22_1","first-page":"928","article-title":"Autism or atypical autism in maternally but not paternally derived proximal 15q duplication","volume":"60","author":"Cook E.","year":"1997","journal-title":"American Journal of Human Genetics"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-006-0301-3"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2007.02.002"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301406"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.5.1.94"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm181"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910297106"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/77040"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-20-08278.2001"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1977.tb00443.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.053107.121225"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07953"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-7-62"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-058-8_18"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5487"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.02.001"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1136"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05526"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-008-0654-7"},{"key":"e_1_2_6_41_1","first-page":"217","article-title":"Autistic disturbances of affective contact","volume":"2","author":"Kanner L.","year":"1943","journal-title":"Nervous Child"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.09.011"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm376"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.03.023"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1086\/382137"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(97)00532-5"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002087"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02216055"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80354-2"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2009.140"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02172145"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31003"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.12.009"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2007.00330.x"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8905"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.122.2.293"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1086\/522307"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-14-05239.2001"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn148"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi016"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1157657"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1848.2004.00076.x"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-1848.2004.00076.x"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.10.029"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2008.00452.x"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200404000-00016"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1352\/2008.113:439-452"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.04.024"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.3"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.03.051"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.03.029"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09146"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2009.00487.x"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21715"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579409990265"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.chi.0000227880.42780.0e"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.06.004"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(61)80261-8"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4091-05.2006"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2125"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2851"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610779104"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1146221"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505312102"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08826"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02276235"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201239"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1086\/426697"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201644"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-006-0196-z"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa075974"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06104"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31032"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.03.013"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns0824s48"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.08.001.2007"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005620107"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.51"}],"container-title":["Autism Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Faur.180","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T12:37:58Z","timestamp":1694522278000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aur.180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,19]]},"references-count":97,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1002\/aur.180"],"URL":"https:\/\/doi.org\/10.1002\/aur.180","archive":["Portico"],"relation":{},"ISSN":["1939-3792","1939-3806"],"issn-type":[{"value":"1939-3792","type":"print"},{"value":"1939-3806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,19]]}}}