{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:14:34Z","timestamp":1791296074158,"version":"4.1.0"},"reference-count":84,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG WO 1732\/1\u20101"],"award-info":[{"award-number":["DFG WO 1732\/1\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008914","name":"Ontario Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["MIND Institute IDDRC\/HD079125"],"award-info":[{"award-number":["MIND Institute IDDRC\/HD079125"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["(ES025570) for JLS"],"award-info":[{"award-number":["(ES025570) for JLS"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["(MH101584) to JDB"],"award-info":[{"award-number":["(MH101584) to JDB"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Mutations in the\n                      <jats:italic>SHANK3<\/jats:italic>\n                      gene have been discovered in autism spectrum disorder (ASD), and the intellectual disability, Phelan\u2010McDermid Syndrome. This study leveraged a new rat model of\n                      <jats:italic>Shank3<\/jats:italic>\n                      deficiency to assess complex behavioral phenomena, unique to rats, which display a richer social behavior repertoire than mice. Uniquely detectable emissions of ultrasonic vocalizations (USV) in rats serve as situation\u2010dependent affective signals and accomplish important communicative functions. We report, for the first time, a call and response acoustic playback assay of bidirectional social communication in juvenile\n                      <jats:italic>Shank3<\/jats:italic>\n                      rats. Interestingly, we found that\n                      <jats:italic>Shank3<\/jats:italic>\n                      \u2010deficient null males did not demonstrate the enhanced social approach behavior typically exhibited following playback of pro\u2010social USV. Concomitantly, we discovered that emission of USV in response to playback was not genotype\u2010dependent and emitted response calls were divergent in meaning. This is the first report of these socially relevant responses using a genetic model of ASD. A comprehensive and empirical analysis of vigorous play during juvenile reciprocal social interactions further revealed fewer bouts and reduced durations of time spent playing by multiple key parameters, including reduced anogenital sniffing and allogrooming. We further discovered that male null\n                      <jats:italic>Shank3\u2010<\/jats:italic>\n                      deficient pups emitted fewer isolation\u2010induced USV than\n                      <jats:italic>Shank3<\/jats:italic>\n                      wildtype controls. Postnatal whole brain anatomical phenotyping was applied to visualize anatomical substrates that underlie developmental phenotypes. The data presented here lend support for the important role of\n                      <jats:italic>Shank3<\/jats:italic>\n                      in social communication, the core symptom domain of ASD. By increasing the number of\n                      <jats:italic>in vivo<\/jats:italic>\n                      functional outcome measures, we improved the likelihood for identifying and moving forward with medical interventions.\n                      <jats:bold>\n                        <jats:italic>Autism Res<\/jats:italic>\n                      <\/jats:bold>\n                      <jats:italic>2018, 11: 587\u2013601<\/jats:italic>\n                      . \u00a9 2018 International Society for Autism Research, Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay Summary<\/jats:title>\n                    <jats:p>\n                      Clinically relevant outcomes are required to demonstrate the utility of therapeutics. We introduce findings in a rat model, and assess the impact of mutations in\n                      <jats:italic>Shank3<\/jats:italic>\n                      , an autism risk gene. We found that males with deficient expression of\n                      <jats:italic>Shank3<\/jats:italic>\n                      did not demonstrate typical responses in a bi\u2010directional social communication test and that social interaction was lower on key parameters. Outcome measures reported herein extend earlier results in mice and capture responses to acoustic calls, which is analogous to measuring receptive and expressive communication.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/aur.1925","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T17:15:27Z","timestamp":1517246127000},"page":"587-601","source":"Crossref","is-referenced-by-count":96,"title":["Developmental social communication deficits in the\n                    <i>Shank3<\/i>\n                    rat model of phelan\u2010mcdermid syndrome and autism spectrum disorder"],"prefix":"10.1002","volume":"11","author":[{"given":"Elizabeth L.","family":"Berg","sequence":"first","affiliation":[{"name":"University of California, Davis, MIND Institute, School of Medicine Sacramento CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nycole A.","family":"Copping","sequence":"additional","affiliation":[{"name":"University of California, Davis, MIND Institute, School of Medicine Sacramento CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef K.","family":"Rivera","sequence":"additional","affiliation":[{"name":"University of California, Davis, MIND Institute, School of Medicine Sacramento CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Pride","sequence":"additional","affiliation":[{"name":"University of California, Davis, MIND Institute, School of Medicine Sacramento CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo","family":"Careaga","sequence":"additional","affiliation":[{"name":"University of California, Davis, MIND Institute, School of Medicine Sacramento CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa D.","family":"Bauman","sequence":"additional","affiliation":[{"name":"University of California, Davis, MIND 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