{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:31:10Z","timestamp":1791538270975,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,4,7]],"date-time":"2011-04-07T00:00:00Z","timestamp":1302134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated repetitive and stereotyped behavior (RSB) and its relationship to morphometric measures of the basal ganglia and thalami in 3\u2010 to 4\u2010year\u2010old children with autism spectrum disorder (ASD; <jats:italic>n<\/jats:italic> = 77) and developmental delay without autism (DD; <jats:italic>n<\/jats:italic> = 34). Children were assessed through clinical evaluation and parent report using RSB\u2010specific scales extracted from the Autism Diagnostic Observation Schedule (ADOS), the Autism Diagnostic Interview, and the Aberrant Behavior Checklist. A subset of children with ASD (<jats:italic>n<\/jats:italic> = 45), DD (<jats:italic>n<\/jats:italic> = 14), and a group of children with typical development (TD; <jats:italic>n<\/jats:italic> = 25) were also assessed by magnetic resonance imaging. Children with ASD demonstrated elevated RSB across all measures compared to children with DD. Enlargement of the left and right striatum, more specifically the left and right putamen, and left caudate, was observed in the ASD compared to the TD group. However, nuclei were not significantly enlarged after controlling for cerebral volume. The DD group, in comparison to the ASD group, demonstrated smaller thalami and basal ganglia regions even when scaled for cerebral volume, with the exception of the left striatum, left putamen, and right putamen. Elevated RSB, as measured by the ADOS, was associated with decreased volumes in several brain regions: left thalamus, right globus pallidus, left and right putamen, right striatum and a trend for left globus pallidus and left striatum within the ASD group. These results confirm earlier reports that RSB is common early in the clinical course of ASD and, furthermore, demonstrate that such behaviors may be associated with decreased volumes of the basal ganglia and thalamus. <jats:bold><jats:italic>Autism Res<\/jats:italic><\/jats:bold> <jats:italic>2011,4:212\u2013220<\/jats:italic>. \u00a9 2011 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/aur.193","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T09:48:31Z","timestamp":1302256111000},"page":"212-220","source":"Crossref","is-referenced-by-count":160,"title":["Basal ganglia morphometry and repetitive behavior in young children with autism spectrum disorder"],"prefix":"10.1002","volume":"4","author":[{"given":"Annette","family":"Estes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W. 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