{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:24:46Z","timestamp":1791581086725,"version":"4.3.4"},"reference-count":73,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>There is substantial evidence of word retrieval impairment as indicated by poor performance on the category fluency test in autism spectrum disorder (ASD). However, little is known about the neural mechanisms underlying this impairment. Functional neuroimaging studies have shown that the lateral frontal cortex plays a key role in flexible word retrieval. Thus, we examined whether individuals with ASD exhibited altered frontal processing during the category fluency test using functional near\u2010infrared spectroscopy (fNIRS). Twenty\u2010two adolescents with high\u2010functioning ASD (20 males) and 22 typically developing (TD) adolescents (16 males) aged 11\u201318\u2009years were recruited. All underwent a category fluency paradigm, which required production of animal or means of transportation words for 1 min each although their frontal hemodynamic changes were recorded with fNIRS. We found that adolescents with ASD produced fewer animal but not transportation words (group\u2010by\u2010category interaction: <jats:italic>P<\/jats:italic>\u2009=\u20090.003), suggesting differential word retrieval impairment. In addition, unlike TD adolescents who exhibited activation primarily in lateral frontal regions during word production, adolescents with ASD had comparable activation across lateral and medial frontal regions. More importantly, this lack of lateral\u2013medial distinction of activation, which was associated with poor word retrieval, differed significantly between groups only in the animal category (group\u2010by\u2010category interaction: <jats:italic>P<\/jats:italic>\u2009=\u20090.018). Thus, our findings implicate frontal lobe dysfunction in the impairment of differential word retrieval in adolescents with ASD. The relatively greater involvement of the medial frontopolar cortex might reflect the use of nonspecialized brain regions to compensate for the category\u2010dependent difficulties with word retrieval in ASD. <jats:italic><jats:bold>Autism Res<\/jats:bold> 2019, 12: 600\u2013613<\/jats:italic>. \u00a9 2019 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>Using an optical imaging tool, we found that adolescents with autism had difficulties with producing semantically related words and exhibited frontal lobe dysfunction. Nonetheless, poor word production and altered brain processing was only seen when these adolescents were asked to produce words from a category of living things but not nonliving things (i.e., animals but not means of transportation). Category\u2010dependent word retrieval problems and frontal lobe dysfunction might be two features of this disorder.<\/jats:p><\/jats:sec>","DOI":"10.1002\/aur.2082","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T13:01:32Z","timestamp":1550062892000},"page":"600-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Frontal lobe dysfunction underlies the differential word retrieval impairment in adolescents with high\u2010functioning autism"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6699-6080","authenticated-orcid":false,"given":"Michael K.","family":"Yeung","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery Montreal Neurological Institute, McGill University  Montreal Quebec Canada"},{"name":"Neuropsychology Laboratory, Department of Psychology The Chinese University of Hong Kong  New Territories Hong 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