{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:56:33Z","timestamp":1792292193429,"version":"4.4.0"},"reference-count":62,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T00:00:00Z","timestamp":1557532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Gaziantep University Faculty of Medicine"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:label\/><jats:p>Changes related to the serotonin system play a key role in the etiology of autism spectrum disorder (ASD). Although we know that platelets are associated with the serotonin system, their relation to ASD has not yet been elucidated. In this study, we aim to investigate platelet parameters in children with ASD. Forty patients with ASD according to Diagnostic and Statistical Manual of Mental Disorders 5 (DSM\u20105) and 30 healthy controls were included in the study. A complete blood count was done to measure parameters relating to platelet morphology. Moreover, prothrombin time (PT) and activated partial thromboplastin time (aPTT) were evaluated. Lastly, platelet functions were assessed with a platelet functions analyzer 100 (PFA\u2010100) device by measuring collagen\u2010ADP and collagen\u2010epinephrine (EPI) closure times. There was not a significant difference between the groups in terms of platelet count, mean platelet volume (MPV), platelet distribution width, plateletcrit, PT, or aPTT parameters for ASD patients when compared to the control group (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). However, MPV in severe ASD, as quantified by the Childhood Autism Rating Scale, was found to be significantly lower when compared to mild to moderate ASD (<jats:italic>P<\/jats:italic> = 0.047). Moreover, in terms of platelet functions, the elongation in collagen\u2010ADP and collagen\u2010EPI closure times were significantly higher for the ASD group (<jats:italic>P<\/jats:italic> = 0.044). These results may suggest an impairment in platelet functions rather than in platelet morphology for children with ASD. Considering these results, further investigation of thrombocyte functions in the ASD may lead to a better understanding of the pathogenesis of ASD and to the development of our limited knowledge of this disorder. <jats:italic><jats:bold>Autism Res<\/jats:bold> 2019, 12: 1069\u20131076<\/jats:italic>. \u00a9 2019 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>Serotonin is a chemical that is found in brain as wells as in blood cells that function in blood clotting in the human body. There are problems related to serotonin in brains of people who have autism. Thus, blood clotting cells may also be affected in people who have autism. In this study, we compare blood clotting functions of children with autism with that of healthy controls.<\/jats:p><\/jats:sec>","DOI":"10.1002\/aur.2122","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T13:37:52Z","timestamp":1557581872000},"page":"1069-1076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of Platelet Parameters in Children with Autism Spectrum Disorder: Elongated Collagen\u2010Adenosine Diphosphate and Collagen\u2010Epinephrine Closure Times"],"prefix":"10.1002","volume":"12","author":[{"given":"Nurdan","family":"Coban","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Gaziantep University  Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem","family":"Gokcen","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Gaziantep University  Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"Akbayram","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Gaziantep University  Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3169-9825","authenticated-orcid":false,"given":"Baran","family":"Calisgan","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Gaziantep University  Gaziantep Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2006.00843.x"},{"issue":"4","key":"e_1_2_7_3_1","first-page":"545","article-title":"Platelet function analyser (PFA)\u2010100 closure time in the evaluation of non\u2010steroidal anti\u2010inflammatory drug\u2010induced platelet dysfunction in children with bleeding symptoms","volume":"10","author":"Akin M.","year":"2012","journal-title":"Blood Transfusion"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1971.tb03433.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-016-0086-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1987.tb00677.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-011-1371-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.5.889"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-015-0051-y"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/226371a0"},{"key":"e_1_2_7_12_1","unstructured":"Buitelaar J.(2014). 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