{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:44:10Z","timestamp":1793065450300,"version":"4.5.0"},"reference-count":82,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81627806"],"award-info":[{"award-number":["81627806"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701665"],"award-info":[{"award-number":["81701665"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91432301"],"award-info":[{"award-number":["91432301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91859121"],"award-info":[{"award-number":["91859121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Autism Research"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>Autism spectrum disorder (ASD) is a general neurodevelopmental disorder associated with altered brain connectivity. However, most connectivity analyses in ASD focus on static functional connectivity, largely neglecting brain activity dynamics that have been reported to provide deeper insight into the underlying mechanisms of brain functions. Therefore, we anticipate that the use of dynamic functional connectivity (DFC) with interaction of clustering measures could help characterize ASD severity and reveal more information. In this study, we applied the sliding\u2010window and k\u2010means clustering methods to perform DFC and clustering analyses in ASD and typically developing (TD) groups. Data from 62 ASD and 63 TD children were acquired from the open\u2010access data set Autism Brain Imaging Data Exchange. Our findings revealed higher DFC variability between the posterior cingulate gyrus (PCC) and middle temporal pole (TPOmid) in subjects with ASD. The connection between the PCC and pars opercularis of inferior frontal gyrus (IFGoper) also presented greater variability in ASD, with the increase depending on ASD symptom severity. Furthermore, clustering analysis showed higher averaged dwell time and probability of transition for globally hyper\u2010connected state in the ASD group, which could be related to connection variability between the PCC and IFGoper. Our results demonstrate that both the PCC and IFGoper play crucial roles in characterizing symptom severity and state configuration in ASD, and brain connectivity dynamics may serve as potential indicators of ASD in future studies. <jats:italic><jats:bold>Autism Res<\/jats:bold> 2020, 13: 230\u2013243<\/jats:italic>. \u00a9 2019 International Society for Autism Research, Wiley Periodicals, Inc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Lay Summary<\/jats:title><jats:p>Dynamic functional connectivity (DFC) refers to functional connectivity that changes over a short time. This study found that DFC instability between the posterior cingulate gyrus and pars opercularis of inferior frontal gyrus is associated with abnormal brain pattern configurations and dysfunction of social cognitive processes in autism spectrum disorder (ASD). These findings could contribute to a deeper understanding of the neural mechanisms of ASD and help characterize ASD severity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/aur.2212","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T22:34:31Z","timestamp":1571178871000},"page":"230-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Dynamic Functional Connectivity Reveals Abnormal Variability and Hyper\u2010connected Pattern in Autism Spectrum Disorder"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3758-5893","authenticated-orcid":false,"given":"Yu","family":"Li","sequence":"first","affiliation":[{"name":"Center for Biomedical Engineering, University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Center for Biomedical Engineering, University of Science and Technology of China  Hefei China"},{"name":"School of Information Engineering, Southwest University of Science and Technology  Mianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedictor Alexander","family":"Nguchu","sequence":"additional","affiliation":[{"name":"Center for Biomedical Engineering, University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Biomedical Engineering, University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Biomedical Engineering, University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bensheng","family":"Qiu","sequence":"additional","affiliation":[{"name":"Center for Biomedical Engineering, University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Biomedical Engineering, University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs352"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1884"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.07.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.05.067"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-0277(85)90022-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23764"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00316"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv051"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.1457"},{"key":"e_1_2_8_12_1","volume-title":"Social responsive scale (SRS) manual","author":"Constantino J.","year":"2005"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.05.024"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2017.10"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.78"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2008.01.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704320104"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.09.034"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00525"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1162\/netn_a_00067"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2015.0389"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.05.059"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350312"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.09.035"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0135058100"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24447"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2019.00006"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2020"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2013.08.003"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2016.00205"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.079"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2014.08.011"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094115"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2014.08.851"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.09.031"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.10.052"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2012.00348"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24590"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt162"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-015-9384-6"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2015.00026"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-013-0641-4"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23430"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23890"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.12.013"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24529"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh199"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.04.069"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-018-3581-2"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2018.09.008"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000317"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm052"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics8030051"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.10.032"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.12.061"},{"key":"e_1_2_8_56_1","doi-asserted-by":"crossref","unstructured":"Price T. Wee C.\u2010Y. Gao W. &Shen D.(2014). Multiple\u2010network classification of childhood autism using functional connectivity dynamics. Paper presented at the International Conference on Medical Image Computing and Computer\u2010Assisted Intervention.","DOI":"10.1007\/978-3-319-10443-0_23"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.04.051"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24064"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.10.043"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr171"},{"key":"e_1_2_8_62_1","volume-title":"The social communication questionnaire: Manual","author":"Rutter M.","year":"2003"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361317709970"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.09.010"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.11.076"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.10.001"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.104"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2010.00021"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00458"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-009-0583-y"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1523980113"},{"key":"e_1_2_8_73_1","first-page":"386","article-title":"GRETNA: a graph theoretical network analysis toolbox for imaging connectomics","volume":"9","author":"Wang J. H.","year":"2015","journal-title":"Frontiers in Human Neuroscience"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20324"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22252"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12499"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1080\/08856257.2010.492928"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy262"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.07.012"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-016-9299-4"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2016.00463"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.07.018"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.041"}],"container-title":["Autism Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.2212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/aur.2212","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/aur.2212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T14:03:46Z","timestamp":1694095426000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/aur.2212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,15]]},"references-count":82,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/aur.2212"],"URL":"https:\/\/doi.org\/10.1002\/aur.2212","archive":["Portico"],"relation":{},"ISSN":["1939-3792","1939-3806"],"issn-type":[{"value":"1939-3792","type":"print"},{"value":"1939-3806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,15]]},"assertion":[{"value":"2019-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}